不同治疗方法在绝经早期妇女中的应用效果对比

发布时间：2018-10-08 15:05

【摘要】：目的探讨不同治疗方法在绝经早期妇女中的应用效果,旨在为今后对绝经早期妇女的治疗提供参考。方法选取2013年5月至2016年5月该院收治的绝经早期妇女2 143例,依据患者自己选择的治疗方式分为A组(雌激素+醋酸甲羟孕酮片)、B组(戊酸雌二醇+醋酸甲羟孕酮片)、C组(戊酸雌二醇+黄体酮胶丸)、D组(坤泰胶囊)、E组(黑升麻提取物),比较不同药物治疗下患者的性激素变化、绝经症状及不良反应。结果治疗后3、6、12个月,A、B、C组患者的雌二醇水平逐渐升高,促卵泡生成素逐渐降低,与治疗前比较差异有统计学意义(P0.05)。D、E组患者的雌二醇有升高趋势,促卵泡生成素无明显变化,二者与治疗前比较差异均无统计学意义(P0.05)。治疗后3、6、12个月,不同药物治疗下患者的改良Kupperman量表评分逐渐降低,与治疗前比较差异有统计学意义(P0.05)。治疗后3、6个月,A、B、C组患者的改良Kupperman量表评分明显低于D、E组(P0.05),治疗后12个月不同药物治疗下患者的改良Kupperman量表评分差异无统计学意义(P0.05)。A、B、C、D、E组的不良反应总发生率分别为43.26%、38.26%、47.02%、13.07%、13.82%,差异有统计学意义(P0.05)。结论激素补充剂和天然药物在改善绝经早期症状方面成效显著,其中激素补充剂见效更快,但不良反应较为明显;天然药物对患者性激素影响不大,可能通过其他途径发挥作用。
[Abstract]:Objective to explore the effect of different treatment methods in early menopausal women, and to provide reference for the treatment of early menopausal women in the future. Methods A total of 2,143 postmenopausal women admitted from May 2013 to May 2016 were selected. The patients were divided into group A (medroxyprogesterone acetate) and group B (estradiol valerate acetate medroxyprogesterone tablets), group C (estradiol valerate progesterone acetate) and group D (kuntai capsule). To compare the changes of sex hormones in patients treated with different drugs. Menopausal symptoms and adverse reactions. Results the level of estradiol and follicle stimulating hormone (FPO) gradually increased and follicle stimulating hormone (FPO) gradually decreased in group A (P 0.05). The level of estradiol in group E was significantly higher than that before treatment (P 0.05), but there was no significant change in follicle stimulating hormone (FPO) in group A (P 0.05) .There was no significant change in the level of estradiol in group A (P 0.05). There was no significant difference between the two groups before treatment (P0.05). The scores of the modified Kupperman scale were gradually decreased after 3 months and 12 months of treatment under different drug treatments, which was significantly different from that before treatment (P0.05). The scores of modified Kupperman scale in group C were significantly lower than those in group E (P0.05). There was no significant difference in scores of modified Kupperman scale for patients treated with different drugs at 12 months after treatment (P0.05). The total incidence of adverse reactions in group C was significantly lower than that in group C (P0.05). The difference was statistically significant (P0.05). Conclusion hormone supplements and natural drugs are effective in improving early menopausal symptoms, among which hormone supplements are more effective, but adverse reactions are more obvious, and natural drugs have little effect on sex hormones in patients. It may work in other ways.
【作者单位】： 四川省绵阳市中医医院妇产科;
【分类号】：R711.75

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