肝内巨噬细胞在糖脂代谢调节中的作用

发布时间：2018-10-15 07:35

【摘要】：免疫细胞参与机体糖脂代谢的调节,特别是组织内巨噬细胞的活化和募集,参与肥胖状态下组织炎症和胰岛素抵抗的发生和发展。肝脏是机体糖脂代谢的重要器官,肝内巨噬细胞与肝脏内的糖脂代谢紊乱存在直接关系。无论肝脏固有的库普弗细胞还是循环中募集而来的巨噬细胞的活化、极化和自噬等改变,都会通过激活炎症信号通路抑制胰岛素信号转导,影响肝脏胰岛素敏感性,造成糖脂代谢异常改变。深入了解肝内巨噬细胞在糖脂代谢中的作用机制,有助于探索相关代谢性疾病新的治疗方向。
[Abstract]:Immune cells are involved in the regulation of glucose and lipid metabolism, especially in the activation and recruitment of macrophages in tissues, and in the occurrence and development of inflammation and insulin resistance in obese tissues. Liver is an important organ of glycolipid metabolism. The changes of activation, polarization and autophagy of the intrinsic Kupffer cells or the circulating macrophages will inhibit the insulin signal transduction by activating the inflammatory signaling pathway and affect the insulin sensitivity of the liver. To cause abnormal changes in glucose and lipid metabolism. A deeper understanding of the role of intrahepatic macrophages in glycolipid metabolism is helpful to explore a new therapeutic direction for metabolic diseases.
【作者单位】：南京中医药大学第一临床医学院代谢病中医研究重点实验室;
【基金】：国家自然科学基金(81473391)
【分类号】：R58

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