不同血糖水平慢性肾脏病患者的液体超负荷、脉搏波传导速度和臂预射血期与臂射血时间比

发布时间：2018-10-16 17:37

【摘要】：目的观察糖尿病和非糖尿病慢性肾脏病(CKD)患者液体超负荷、脉搏波传导速度和臂预射血期与臂射血时间比。方法 480例4~5期CKD患者纳入研究。液体状态采用生物阻抗光谱学方法,检测臂踝脉搏波速度(baPWV)、臂预射血期(bPEP)/臂射血时间(bET)和踝-臂指数(ABI)。结果糖尿病207例,非糖尿病273例,其中240例(50%)存在体液超负荷。非糖尿病CKD患者体液超负荷与女性(β=-2.87,P=0.003)、心脏病变(β=2.69,P=0.04)、高baPWV(β=0.27,P=0.04)、低血红蛋白(β=-1.10,P0.001)、低白蛋白水平(β=-5.21,P0.001)相关。糖尿病CKD患者体液超负荷与利尿剂应用(β=3.69,P=0.003)、高平均动脉压(β=0.14,P=0.01)、低bPEP/ET(β=-0.19,P=0.03)、低血红蛋白(β=-1.55,P=0.001)、低白蛋白水平(β=-9.46,P0.001)相关。结论 baPWV与非糖尿病CKD患者体液超负荷相关,bPEP/bET与糖尿病CKD患者体液超负荷相关;早期精确评估这些与心血管危险因素可能会使CKD患者的治疗效果得到改善。
[Abstract]:Objective to observe the ratio of fluid overload, pulse wave velocity and forearm ejection time to (CKD) in diabetic and non diabetic patients with chronic kidney disease. Methods 480 patients with stage 4 CKD were included in the study. The brachial ankle pulse wave velocity (baPWV),) / brachial ejection time (bET) and malleolus brachial index (ABI).) were measured by bioimpedance spectroscopy (BIS) in liquid state. Results there were 207 cases of diabetes mellitus and 273 cases of non-diabetes mellitus, of which 240 cases (50%) had body fluid overload. Body fluid overload in non-diabetic patients with CKD was associated with female (尾 = -2.87), cardiac disease (尾 = 2.69), high baPWV (尾 = 0.27), low hemoglobin (尾 = -1.10) and low albumin (尾 = -5.21 P0.001). High mean arterial pressure (尾 = 0.14, P < 0.01), low bPEP/ET (尾 = -0.19), low hemoglobin (尾 = -1.55P ~ (0. 001) and low albumin (尾 = -9.46) were associated with body fluid overload and diuretic therapy (尾 = 3.69, P0. 003), high mean arterial pressure (尾 = 0. 14, P0. 01), low hemoglobin (尾 =-1. 55, P0. 001) and low albumin levels (尾 =-9. 46, P0. 001) in patients with CKD. Conclusion baPWV is associated with body fluid overload in non-diabetic CKD patients, and bPEP/bET is associated with body fluid overload in diabetic CKD patients, and early and accurate evaluation of these cardiovascular risk factors may improve the therapeutic efficacy of CKD patients.
【作者单位】：河南煤化集团鹤壁煤业公司总医院肾病科;
【分类号】：R587.2;R692.9

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