2型糖尿病患者颈动脉病变与血小板指数及血尿酸的相关性研究
发布时间：2018-10-22 15:14
【摘要】：目的:目前国内、外有关血尿酸(UA)对2型糖尿病大血管病影响的研究比较普遍,而有关血小板指数与血尿酸(UA)的相关性研究比较少,本研究通过分析2型糖尿病患者颈动脉病变与血尿酸(UA)及血小板指数的相关性,为2型糖尿病患者颈动脉粥样硬化的早期防治提供理论依据。同时也为我国许多不具备超声或核磁共振等的大型设备检查的基层医院及乡镇卫生院,初步推断早期2型糖尿病动脉硬化提供一定的理论参考。方法:近2年大连大学附属中山医院内分泌科住院治疗的2型糖尿病患者为研究对象,定义为研究组,检测颈动脉超声测定内-中膜厚度,根据颈动脉内-中膜厚度分为2亚组:颈动脉增厚组138例(1.0mm内-中膜厚度≤1.2mm)。颈动脉增厚并斑块组154例(颈动脉内中膜厚度1.2mm)。以同期来我院进行健康检查的健康人群为对照组,共236例。比较研究组及对照组各血液指标的差异。结果:(1)研究组及对照组总胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白胆固醇(LDL-C)、血清高密度脂蛋白胆固醇(HDL-C)、体重指数(BMI)、血小板压积(PCT)、血小板分布宽度(PDW)、血小板计数(PLT)差异无统计学意义(P0.05)。(2)研究组糖化血红蛋白(HBA1C)、空腹血糖(FPG)、血尿酸(UA)、平均血小板体积(MPV)均高于对照组(P0.05)(3)颈动脉增厚组中尿酸增高者MPV高于非尿酸增高者(P0.05),颈动脉增厚组中尿酸增高者与非尿酸增高者,PLT、PCT、PDW差异无统计学意义(P0.05)。(4)颈动脉增厚并斑块组中尿酸增高者MPV高于非尿酸增高者(P0.05),颈动脉增厚组中尿酸增高者与非尿酸增高者,PLT、PCT、PDW差异无统计学意义(P0.05)。结论:2型糖尿病患者出现颈动脉病变后,血尿酸水平升高。血尿酸可作为预测2型糖尿病外周血管病变的指标,MPV与血尿酸增高也具有一定的相关性。
[Abstract]:Objective: at present, the effect of serum uric acid (UA) on type 2 diabetic macroangiopathy is common in China and abroad, but the correlation between platelet index and serum uric acid (UA) is less. In this study, the relationship between carotid artery lesions and serum uric acid (UA) and platelet index in type 2 diabetes mellitus was analyzed to provide theoretical basis for early prevention and treatment of carotid atherosclerosis in patients with type 2 diabetes mellitus. At the same time, it also provides a theoretical reference for many basic hospitals and township hospitals that do not have ultrasound or nuclear magnetic resonance examination, and preliminarily infer early type 2 diabetic arteriosclerosis. Methods: type 2 diabetic patients who were hospitalized in Department of Endocrinology of Zhongshan Hospital affiliated to Dalian University in recent 2 years were studied and defined as study group. Carotid ultrasound was used to measure the thickness of medial media. According to the intima-media thickness of carotid artery, the patients were divided into two subgroups: 138 cases of carotid artery thickening group (1.0mm IMT 鈮，
本文编号：2287518
[Abstract]:Objective: at present, the effect of serum uric acid (UA) on type 2 diabetic macroangiopathy is common in China and abroad, but the correlation between platelet index and serum uric acid (UA) is less. In this study, the relationship between carotid artery lesions and serum uric acid (UA) and platelet index in type 2 diabetes mellitus was analyzed to provide theoretical basis for early prevention and treatment of carotid atherosclerosis in patients with type 2 diabetes mellitus. At the same time, it also provides a theoretical reference for many basic hospitals and township hospitals that do not have ultrasound or nuclear magnetic resonance examination, and preliminarily infer early type 2 diabetic arteriosclerosis. Methods: type 2 diabetic patients who were hospitalized in Department of Endocrinology of Zhongshan Hospital affiliated to Dalian University in recent 2 years were studied and defined as study group. Carotid ultrasound was used to measure the thickness of medial media. According to the intima-media thickness of carotid artery, the patients were divided into two subgroups: 138 cases of carotid artery thickening group (1.0mm IMT 鈮，
本文编号：2287518
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