中老年汉族男性2型糖尿病患者合并骨质疏松的危险因素

发布时间：2018-10-24 15:45

【摘要】：目的探讨中老年汉族男性2型糖尿病(T2DM)患者合并骨质疏松(OP)的危险因素。方法选择汉族T2DM男性患者115例(T2DM组)及50~79岁健康男性汉族体检人群148例(对照组)。观察T2DM组、对照组的OP发病率的关系。比较T2DM腰椎1~4、股骨颈、全髋部位的骨密度(BMD)与龄、体重指数(BMI)分层的关系,同时进行T2DM组相关因素的分析。结果中老年汉族男性T2DM患者OP的发病率是13.8%,明显高于对照组(2.7%,P0.05)。T2DM组腰椎1~4、股骨颈、全髋的BMD与年龄、BMI分层无相关性(P0.05)。多元线性回归分析结果显示糖尿病病程、饮酒史与BMD独立正相关(P0.05);BMI、游离三碘甲状腺原氨酸(FT3)与BMD独立负相关(P0.01),高密度脂蛋白胆固醇(HDL-C)、甲状腺球蛋白抗体(TgAb)与BMD呈独立负相关(P0.05)。结论 BMI、糖尿病病程延长、长期饮酒及高水平FT3、TgAb、HDL-C是中老年汉族男性T2DM患者发生OP的重要风险因素。
[Abstract]:Objective to investigate the risk factors of type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP) in middle aged Han nationality men. Methods 115 T2DM male patients in Han nationality (T2DM group) and 148 healthy Han people aged 50 to 79 years (control group) were selected. The incidence of OP in T2DM group and control group was observed. The correlation between BMD (BMD) and age, body mass index (BMI) in T2DM lumbar vertebrae, femoral neck and total hip were compared. The correlation factors of T2DM group were analyzed. Results the incidence of OP in middle-aged and aged Han men with T2DM was 13.8, which was significantly higher than that in control group (P0.05). There was no correlation between BMD of lumbar vertebrae, femoral neck, total hip and age, BMI stratification in T2DM group (P0.05). Multiple linear regression analysis showed that the course of diabetes, alcohol consumption history and BMD independent positive correlation (P0.05); BMI, free triiodothyronine (FT3) and BMD independent negative correlation (P0.01), high density lipoprotein cholesterol (HDL-C), thyroglobulin antibody (TgAb) and BMD were independent negative correlation (P0.05). Conclusion prolonged duration of BMI, diabetes, long-term drinking and high level of FT3,TgAb,HDL-C are important risk factors for OP in middle and aged Han male patients with T2DM.
【作者单位】：北京市垂杨柳医院内分泌科;中国医学科学院阜外医院心内科;首都师范大学社区卫生服务中心内科;
【分类号】：R580;R587.1

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