载脂蛋白M与2型糖尿病下肢血管病变的相关性研究

发布时间：2018-10-25 15:42

【摘要】：目的研究2型糖尿病患者下肢血管病变与血浆载脂蛋白M(apolipoprotein M,Apo M)的相关性。方法收集2014年9月-2016年6月在第三军医大学大坪医院野战外科研究所高血压内分泌科住院治疗的2型糖尿病合并下肢血管病变患者75例、单纯2型糖尿病未合并下肢血管病变患者62例以及正常对照组的志愿者57例,采集一般情况并完善脂代谢、生化、肾功、血管功能、颈动脉内膜中膜厚度、下肢动脉CT成像或血管造影等辅助检查,采集血浆后利用酶联免疫吸附法检测血浆中Apo M的表达水平,利用Spearman相关分析明确Apo M表达水平同脂代谢、血管病变参数以及其他指标的相关性。结果 3组受试者的一般情况以及脂代谢指标差异无统计学意义,2型糖尿病合并下肢血管病变患者具有更低的踝臂指数和趾臂指数及更高的颈动脉内膜中膜厚度;2型糖尿病合并下肢血管病变的患者血浆Apo M的值为9.4(6.91,11.74)mg/L,显著低于正常对照组[18.45(15.10,23.93)mg/L,P0.001]和单纯2型糖尿病组[15.76(11.79,18.63)mg/L,P0.001];进一步通过相关分析表明,除同脂代谢指标相关外,Apo M同血管病变参数[ABI(r2=0.229)、TBI(r2=0.252)、IMT(r2=-0.247,r2=-0.259)]、超敏C反应蛋白(r2=-0.229)和吸烟量(r2=-0.173)呈显著相关。结论 Apo M可能通过调控脂代谢进而抑制2型糖尿病的动脉粥样硬化进展。
[Abstract]:Objective to study the correlation between lower extremity vascular lesions and plasma apolipoprotein M (apolipoprotein moiety (apo M) in patients with type 2 diabetes. Methods from September 2014 to June 2016, 75 patients with type 2 diabetes mellitus complicated with lower extremity vascular diseases were collected and treated in Department of Hypertension and Endocrinology, Department of Field surgery, Daping Hospital, third military Medical University. 62 patients with type 2 diabetes without lower extremity vascular disease and 57 normal volunteers were collected to improve lipid metabolism, biochemistry, renal function, vascular function and carotid intima-media thickness. The expression of Apo M in plasma was detected by enzyme linked immunosorbent assay (Elisa), and the expression level of Apo M was determined by Spearman correlation analysis. Correlation of vascular lesion parameters and other indexes. Results there was no significant difference in general condition and lipid metabolism index among the three groups. The patients with type 2 diabetes mellitus complicated with lower extremity vascular disease had lower malleolus brachial index, lower toe arm index and higher carotid intima-media thickness. The levels of plasma Apo M in patients with type 2 diabetes mellitus complicated with lower extremity vascular disease were significantly lower than those in normal control group [18.45 (15.1023.93) mg/L,P0.001] and type 2 diabetes mellitus group [15.76 (11.79 卤18.63) mg/L,P0.001], which were significantly lower than those in normal control group (6.91 卤11.74) mg/L, and type 2 diabetes mellitus group [15.76 (11.79 卤18.63) mg/L,P0.001]. There was a significant correlation between, Apo M and vascular disease parameters (ABI (r20.229), TBI (R2O0.252), IMT (r2O- 0.259), hypersensitive C-reactive protein (r2mg-0.229) and smoking volume (r2n-0.173). Conclusion Apo M may inhibit the progression of atherosclerosis in type 2 diabetes by regulating lipid metabolism.
【作者单位】：第三军医大学大坪医院野战外科研究所高血压内分泌科全军高血压代谢病中心重庆市高血压研究所;
【基金】：国家重点基础研究发展计划(973计划,2013CB531104)~~
【分类号】：R587.2;R543

【相似文献】