老年糖尿病酮症酸中毒患者外周血氧化应激及炎症指标的改变

发布时间：2018-11-07 07:17

【摘要】：目的分析老年糖尿病酮症酸中毒患者外周血氧化应激及炎症指标的改变。方法老年糖尿病酮症酸中毒患者45例为观察组,同期老年糖尿病患者50例为对照组(不合并酮症酸中毒)。对比两组外周血氧化应激及炎症指标,并分析与空腹血糖间的相关性。结果观察组外周血谷胱甘肽过氧化物酶(GSH-Px)及超氧化物歧化酶(SOD)水平显著低于对照组(P0.05),而丙二醛(MDA)水平显著高于对照组(P0.05)。观察组外周血肿瘤坏死因子(TNF)-α水平显著高于对照组(P0.05)。观察组平均空腹血糖水平为(21.3±4.6)mmol/L。观察组空腹血糖水平与MDA(r=0.794,P0.05)及TNF-α(r=0.720,P0.05)水平呈正相关,而与GSH-Px(r=-0.777,P0.05)及SOD(r=-0.718,P0.05)水平呈负相关。结论老年糖尿病酮症酸中毒患者存在严重的系统性氧化应激及炎症,且与血糖水平显著相关。
[Abstract]:Objective to analyze the changes of peripheral blood oxidative stress and inflammation in elderly patients with diabetic ketoacidosis. Methods 45 cases of senile diabetic ketoacidosis were treated as observation group and 50 cases of senile diabetes as control group (without ketone acidosis). The indexes of oxidative stress and inflammation in peripheral blood of the two groups were compared and the correlation with fasting blood glucose was analyzed. Results the levels of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in peripheral blood of the observation group were significantly lower than those in the control group (P0.05), while the (MDA) level of malondialdehyde was significantly higher than that of the control group (P0.05). The level of tumor necrosis factor (TNF)-伪 in peripheral blood of observation group was significantly higher than that of control group (P 0.05). The mean fasting blood glucose level in the observation group was (21.3 卤4.6) mmol/L.. The fasting blood glucose level in the observation group was positively correlated with the levels of MDA (r-0.794) and TNF- 伪 (r-0.720), but negatively correlated with the levels of GSH-Px (r-0.777) and SOD (r-0.718). Conclusion there are severe systemic oxidative stress and inflammation in elderly patients with diabetic ketoacidosis, and there is a significant correlation with blood glucose level.
【作者单位】：海南医学院第二附属医院急诊科;
【基金】：海南省自然科学基金项目(No.20158316)
【分类号】：R587.2

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