抗C反应蛋白单体抗体在系统性红斑狼疮中的作用

发布时间：2018-11-08 07:05

【摘要】：目的观察系统性红斑狼疮患者中抗C反应蛋白单体抗体水平的变化与疾病活动度之间的关系。方法以天然的CRP为抗原,用酶联免疫吸附方法对实验组30名系统性红斑狼疮患者、疾病对照组(30例其他风湿性疾病,包括原发性干燥综合征,类风湿性关节炎,强直性脊柱炎,骨关节炎)和正常对照组(30例健康体检组)血清中的抗mCRP抗体水平,同时检测系统性红斑狼疮患者血清中的CRP、ESR、FET,记录患者各项临床表现及实验室指标,分析抗mCRP抗体与疾病活动度之间的关系。结果系统性红斑狼疮患者的抗mCRP抗体水平明显高于疾病对照组及健康对照组,差异有统计学意义(t=2.526,5.456,P均0.01);疾病对照组与健康对照组的抗mCRP抗体水平相比较,疾病对照组明显高于健康对照组,差异有统计学意义(t=3.628,P0.01)。与稳定组相比,轻、中、重度活动组SLE患者抗mCRP抗体水平均明显高于稳定组(P均0.01)。差异均有统计学意义。且随着疾病活动度的增加,抗mCRP抗体水平也增加,与SLE患者的SLEDAI计分的高低呈正相关(r=0.238,P0.01)。抗mCRP抗体阳性组与阴性组相比较,阳性组ESR明显增快(t=2.156,P0.01),抗mCRP抗体水平与ESR呈正相关(r=0.463,P0.01),差异有统计学意义;而在CRP、白细胞、血小板、C3、铁蛋白等方面,差异均无统计学意义(P0.05)。结论抗mCRP抗体水平高低与SLE患者的ESR、SLEDAI评分呈正相关。抗mCRP抗体水平与SLE患者的疾病活动度密切相关,可以成为预测SLE患者的疾病活动度指标之一。
[Abstract]:Objective to investigate the relationship between the level of anti C reactive protein monomer antibody and disease activity in patients with systemic lupus erythematosus (SLE). Methods using natural CRP as antigen, 30 patients with systemic lupus erythematosus and 30 patients with other rheumatic diseases, including primary Sjogren's syndrome and rheumatoid arthritis, were studied by enzyme-linked immunosorbent assay (Elisa). Serum levels of anti mCRP antibody in ankylosing spondylitis, osteoarthritis) and normal control group (30 healthy controls) and CRP,ESR,FET, in serum of patients with systemic lupus erythematosus were also detected. The clinical manifestations and laboratory indexes were recorded and the relationship between anti-mCRP antibody and disease activity was analyzed. Results the level of anti mCRP antibody in patients with systemic lupus erythematosus was significantly higher than that in the disease control group and the healthy control group (P 0.01). Compared with the healthy control group, the level of anti mCRP antibody in the disease control group was significantly higher than that in the healthy control group (t = 3.628, P 0.01). Compared with the stable group, the level of anti mCRP antibody in the mild, moderate and severe active SLE group was significantly higher than that in the stable group (P0.01). The difference was statistically significant. With the increase of disease activity, the level of anti mCRP antibody also increased, which was positively correlated with the SLEDAI score of SLE patients (r = 0.238, P 0.01). Compared with the negative group, the ESR of the positive group increased significantly (t = 2.156, P0.01), and the level of anti-mCRP antibody was positively correlated with the ESR (r = 0.463, P 0.01), the difference was statistically significant. However, there was no significant difference in white blood cell, platelet, C _ 3, ferritin and so on in CRP, (P0.05). Conclusion the level of anti-mCRP antibody is positively correlated with the ESR,SLEDAI score of SLE patients. The level of anti-mCRP antibody is closely related to the disease activity of SLE patients and can be used as a predictor of disease activity in SLE patients.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.241

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