帕夫林联合硫酸羟氯喹片治疗气阴两虚型干燥综合征的疗效观察

发布时间：2018-11-09 07:53

【摘要】：目的:观察帕夫林联合硫酸羟氯喹片治疗干燥综合征气阴两虚型患者60例的临床疗效。材料与方法:选择60例符合干燥综合征气阴两虚型诊断标准的患者,随机分为治疗组30例和对照组30例。治疗组采用硫酸羟氯喹片联合帕夫林治疗。对照组仅使用硫酸羟氯喹片进行治疗。实验设计以30天为一个疗程,观察六个疗程后,临床有效率,缓解口干、眼干症状积分,饮水量和血沉的变化作为评定标准,对两组患者的临床病例数据进行统计学分析,进而分析帕夫林联合辨证论治对干燥综合征治疗的临床疗效及优势特点。结果:1.观察六个疗程后治疗组与对照组的疗效。治疗组总有效率93.3%;对照组总有效率86.7%。组间比较存在显著差异(P0.05),表示治疗组的疗效优于对照组。2.治疗组与对照组经过六个疗程治疗后,组间比较口干、眼干、饮水量、血沉各项指标比较有极显著差异(P0.01),说明治疗组的总体疗效优于对照组。此外,各项指标组内比较,也有显著差异(P0.05),说明治疗组与对照组的患者病情均有不同程度改善。结论:1.帕夫林联合硫酸羟氯喹片法治疗干燥综合征气阴两虚型获得了较好的疗效,比单纯应用硫酸羟氯喹片疗效好。2.白芍总苷胶囊(帕夫林)为新型免疫调节药,起到了调理脏腑气血,提高人体免疫力的作用。能缓解患者的症状和体征,配合慢作用抗风湿药治疗可以提高疗效。
[Abstract]:Objective: to observe the clinical effect of Pavlin combined with hydroxychloroquine sulfate in treating 60 cases of Sjogren syndrome with deficiency of qi and yin. Materials and methods: sixty patients with Sjogren syndrome were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with hydroxychloroquine sulfate combined with Pavlin. The control group was treated only with hydroxychloroquine sulfate tablets. The experimental design took 30 days as a course of treatment, observed six courses of treatment, the clinical effective rate, relief of dry mouth, dry eye symptom score, drinking water and erythrocyte sedimentation rate as the evaluation criteria, the two groups of patients' clinical case data were statistically analyzed. Furthermore, the clinical curative effect and advantages of Paflin combined with syndrome differentiation in the treatment of Sjogren's syndrome were analyzed. The result is 1: 1. To observe the curative effect of treatment group and control group after six courses of treatment. The total effective rate was 93. 3% in the treatment group and 86. 7% in the control group. There was significant difference between groups (P0.05), indicating that the curative effect of the treatment group was better than that of the control group. 2. After six courses of treatment, there were significant differences in dry mouth, dry eyes, drinking water and ESR between the treatment group and the control group (P0.01), which indicated that the overall curative effect of the treatment group was better than that of the control group. In addition, there were significant differences in each index group (P0.05), indicating that the patients in the treatment group and the control group improved in varying degrees. Conclusion: 1. Paflin combined with hydroxychloroquine sulfate was better than hydroxychloroquine sulfate in treating Sjogren syndrome with deficiency of qi and yin. 2. Total glucoside of paeony (Pavlin) is a new immunomodulatory drug, which can regulate viscera qi and blood and improve immunity of human body. Can alleviate the symptoms and signs of patients, combined with slow effect of anti-rheumatism drugs can improve the efficacy.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R593.2

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