血浆和肽素水平对糖尿病视网膜病变的诊断价值
发布时间：2018-11-11 09:09
【摘要】：目的探讨血浆和肽素(copeptin)水平对糖尿病视网膜病变(DR)的诊断价值。方法选择2型糖尿病(T2DM)患者217例,根据DR分期标准,无视网膜病变83例(NDR组)、非增殖性视网膜病变98例(NPDR组)、增殖性视网膜病变36例(PDR)组,另选同期体检健康者100例(对照组)。各组均检测血压[收缩压(SBP)、舒张压(DBP)],血浆copeptin、空腹血糖(FPG)、空腹胰岛素(FINS)、Hb A1C、高敏C反应蛋白(hs-CRP)、血脂(TC、TG、HDL-C、LDL-C),计算胰岛素抵抗指数(HOMA-IR)。分析血浆copeptin水平与血压、糖尿病病程及血生化指标的关系。采用受试者工作特征(ROC)曲线预测血浆copeptin对NPDR或PDR的诊断价值。结果 T2DM患者血浆copeptin水平明显高于对照组(P均0.05),且随着疾病进展,血浆copeptin水平逐渐升高(P均0.05)。相关分析显示,T2DM患者血浆copeptin水平与糖尿病病程、Hb A1C、HOMA-IR、Hs-CRP呈正相关(r分别为0.624、0.740、0.872、0.686,P均0.05),与血压、血脂、FPG均无明显相关性(P均0.05)。血浆copeptin诊断NPDR的最佳临界值为24.6 pmol/L,敏感性为79.7%,特异性为71.6%,ROC曲线下面积(AUC)为0.871(95%CI为0.746~0.996,P0.05);血浆copeptin诊断PDR的最佳临界值为28.3 pmol/L,敏感性为78.1%,特异性为82.1%,AUC为0.821(95%CI为0.695~0.948,P0.05)。结论血浆copeptin水平能够为诊断DR提供参考。
[Abstract]:Objective to investigate the diagnostic value of plasma and peptide (copeptin) levels in diabetic retinopathy (DR). Methods 217 patients with type 2 diabetes mellitus (T2DM) were selected. According to the DR staging criteria, 83 cases of non-retinopathy (NDR group), 98 cases of non-proliferative retinopathy (NPDR group) and 36 cases of proliferative retinopathy (PDR) group) were selected. 100 healthy subjects (control group) were selected. Blood pressure [systolic pressure (SBP), diastolic blood pressure], plasma copeptin, fasting blood glucose, fasting insulin (FINS), Hb A1C, Gao Min C-reactive protein (hs-CRP), blood lipid (TC,TG,HDL-C,LDL-C) were measured in all groups. Insulin resistance index (HOMA-IR) was calculated. The relationship between plasma copeptin level and blood pressure, course of diabetes and blood biochemical index was analyzed. The diagnostic value of plasma copeptin for NPDR or PDR was predicted by using the operating characteristic (ROC) curve. Results the plasma copeptin level in T2DM patients was significantly higher than that in the control group (P 0.05), and the plasma copeptin level gradually increased with the progression of the disease (P 0.05). Correlation analysis showed that the plasma copeptin level in T2DM patients was positively correlated with the course of diabetes, Hb A1CnHOMA-IRH Hs-CRP (r = 0.624 0. 740 0. 872 卤0. 686 卤0. 05), and with blood pressure and blood lipid. No significant correlation was found in FPG (all P 0. 05). The best critical value for the diagnosis of NPDR by plasma copeptin was 24.6 pmol/L, the sensitivity was 79.7, the specificity was 71.6 and the area under the ROC curve was 0.871 (95%CI 0.7460.996p0.05). The best critical value of plasma copeptin for the diagnosis of PDR was 28.3 pmol/L, the sensitivity was 78.1, the specificity was 82.1 and the specificity was 0.821 (95%CI: 0.695, 0.948, P0.05). Conclusion Plasma copeptin level can provide reference for diagnosis of DR.
【作者单位】： 武汉科技大学附属普仁医院;临沂市中医医院;
【分类号】：R587.2;R774.1
本文编号：2324392
[Abstract]:Objective to investigate the diagnostic value of plasma and peptide (copeptin) levels in diabetic retinopathy (DR). Methods 217 patients with type 2 diabetes mellitus (T2DM) were selected. According to the DR staging criteria, 83 cases of non-retinopathy (NDR group), 98 cases of non-proliferative retinopathy (NPDR group) and 36 cases of proliferative retinopathy (PDR) group) were selected. 100 healthy subjects (control group) were selected. Blood pressure [systolic pressure (SBP), diastolic blood pressure], plasma copeptin, fasting blood glucose, fasting insulin (FINS), Hb A1C, Gao Min C-reactive protein (hs-CRP), blood lipid (TC,TG,HDL-C,LDL-C) were measured in all groups. Insulin resistance index (HOMA-IR) was calculated. The relationship between plasma copeptin level and blood pressure, course of diabetes and blood biochemical index was analyzed. The diagnostic value of plasma copeptin for NPDR or PDR was predicted by using the operating characteristic (ROC) curve. Results the plasma copeptin level in T2DM patients was significantly higher than that in the control group (P 0.05), and the plasma copeptin level gradually increased with the progression of the disease (P 0.05). Correlation analysis showed that the plasma copeptin level in T2DM patients was positively correlated with the course of diabetes, Hb A1CnHOMA-IRH Hs-CRP (r = 0.624 0. 740 0. 872 卤0. 686 卤0. 05), and with blood pressure and blood lipid. No significant correlation was found in FPG (all P 0. 05). The best critical value for the diagnosis of NPDR by plasma copeptin was 24.6 pmol/L, the sensitivity was 79.7, the specificity was 71.6 and the area under the ROC curve was 0.871 (95%CI 0.7460.996p0.05). The best critical value of plasma copeptin for the diagnosis of PDR was 28.3 pmol/L, the sensitivity was 78.1, the specificity was 82.1 and the specificity was 0.821 (95%CI: 0.695, 0.948, P0.05). Conclusion Plasma copeptin level can provide reference for diagnosis of DR.
【作者单位】： 武汉科技大学附属普仁医院;临沂市中医医院;
【分类号】：R587.2;R774.1
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