原发性甲状旁腺功能亢进症与甲状腺疾病的关系探讨

发布时间：2018-11-13 07:51

【摘要】：目的分析原发性甲状旁腺功能亢进症(primary hyperparathyroidism,PHPT)病人伴发甲状腺病变的发病情况,探讨PHPT与甲状腺疾病的关系。方法回顾分析84例PHPT病人资料,统计PHPT合并甲状腺病变的详细发病情况及PHPT对病人甲状腺功能的影响,使用SPSS统计软件分析PHPT与甲状腺疾病的相关性以及PHPT对病人甲状腺功能的影响。结果本组PHPT病例合并甲状腺疾病主要为结节性甲状腺肿(62/74),其中单发结节性甲状腺肿25例(33.8%),多发结节为37例(50.0%),甲状腺毮样癌(medullary thyroid carcinoma,MTC)病人12例(16.2%)。PHPT病人总T4(total tetraiodothyronine,TT4)及游离T4(free tetraiodothyronine,FT4)浓度较正常成年人降低(P0.05)。TT4及FT4均与甲状旁腺激素(serum parathyroid hormone,PTH)浓度呈负相关(P0.05)。结论 PHPT病人甲状腺疾病高发,且TT4及FT4浓度较正常成年人降低,其原因可能与高PTH相关。
[Abstract]:Objective to investigate the relationship between PHPT and thyroid disease in patients with primary hyperparathyroidism (primary hyperparathyroidism,PHPT). Methods the data of 84 patients with PHPT were analyzed retrospectively. The incidence of PHPT complicated with thyroid lesions and the effect of PHPT on thyroid function were analyzed retrospectively. The correlation between PHPT and thyroid disease and the effect of PHPT on thyroid function were analyzed by SPSS software. Results PHPT patients with thyroid diseases were mainly nodular goiter (62 / 74), including 25 cases (33.8%) with single nodular goiter, 37 cases (50.0%) with multiple nodule, and (medullary thyroid carcinoma, with thyroid carcinoma. The concentrations of total T4 (total tetraiodothyronine,TT4) and free T4 (free tetraiodothyronine,FT4) in 12 patients with MTC (16.2%). PHPT) were lower than those in normal adults (P0.05). TT4 and FT4 were associated with the parathyroid hormone (serum parathyroid hormone,. The concentration of PTH was negatively correlated (P0.05). Conclusion there is a high incidence of thyroid disease in patients with PHPT, and the concentrations of TT4 and FT4 are lower than those of normal adults, which may be related to high PTH.
【作者单位】：首都医科大学附属北京世纪坛医院内分泌科;
【基金】：中国铁路总公司科技研究开发计划课题(J2016Z029)~~
【分类号】：R581;R582.1

【相似文献】