三代头孢类抗菌药物在糖尿病并发泌尿系统感染患者中的疗效分析

发布时间：2018-11-13 09:57

【摘要】：目的探究三代头孢抗菌药物在糖尿病并发泌尿系统感染患者中的疗效。方法选取2012年1月-2015年6月医院收治的泌尿系统感染的糖尿病患者86例作为研究对象,将研究对象按照随机数表法分成三组,A组患者29例,B组患者29例,C组患者28例,三组患者分别给予三种三代头孢抗菌药物进行治疗,A组患者静脉滴注头孢他啶治疗;B组患者静脉滴注头孢曲松治疗;C组患者静脉滴注头孢噻肟治疗,分析三组患者的病原菌的类型以及分布情况,比较三组患者的治疗效果、病原菌的清除率及不良反应发生率。结果 86例患者共检出病原菌133株,革兰阴性菌98株占73.68%,革兰阳性菌30株占22.56%,真菌5株占2.76%;治疗一个疗程后,C组患者治疗的有效率最高为75.00%,其次为B组和A组,分别是58.62%和65.52%,三组比较差异有统计学意义(P0.05),三组患者细菌清除率最高的是C组为73.33%,A组和B组的细菌清除率分别为62.79%和64.44%,三组比较差异有统计学意义(P0.05)。三组患者在治疗结束之后均有部分患者出现不良反应,A、B、C组患者的不良反应率分别为20.86%、17.24%、7.14%。三组患者比较差异有统计学意义(P0.05)。结论三代头孢抗菌药物中,头孢噻肟治疗糖尿病并发泌尿系统感染的效果最好,其次是头孢曲松和头孢他啶,但三种抗菌药物均会引起不良反应。
[Abstract]:Objective to investigate the efficacy of three generations of cephalosporal antibiotics in patients with diabetes mellitus complicated with urinary system infection. Methods from January 2012 to June 2015, 86 patients with urinary tract infection were divided into three groups: group A (29 cases), group B (29 cases) and group C (28 cases). Three groups of patients were treated with three kinds of third-generation ceftazidime respectively. Group A patients were treated with ceftazidime intravenously. Group B patients were treated with ceftriaxone intravenously. Group C patients were treated by intravenous infusion of cefotaxime. The types and distribution of pathogenic bacteria were analyzed. The therapeutic effect, the clearance rate and the incidence of adverse reactions of the three groups were compared. Results 133 strains of pathogenic bacteria were detected in 86 patients, 98 strains of Gram-negative bacteria accounted for 73.68 strains, 30 strains of Gram-positive bacteria accounted for 22.56% and 5 strains of fungi accounted for 2.76%. After a course of treatment, the highest effective rate in group C was 75.00, followed by group B and group A, which were 58.62% and 65.52%, respectively. The difference among the three groups was statistically significant (P0.05). The highest bacterial clearance rate of the three groups was 73.33 in group C and 62.79% in group A and 64.44g in group B respectively. The differences among the three groups were statistically significant (P0.05). After the treatment, some of the patients in the three groups had adverse reactions, and the adverse reaction rates of the patients in group A and B were 20.86 and 17.247.14, respectively. The difference among the three groups was statistically significant (P0.05). Conclusion Cefotaxime is the best in the treatment of diabetes mellitus complicated with urinary system infection, followed by ceftriaxone and ceftazidime.
【作者单位】：新疆生产建设兵团第一师医院老年病科;新疆生产建设兵团第一师医院科教科;新疆生产建设兵团第一师医院创伤骨科;
【分类号】：R587.2;R691.3

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