深海鱼油对2型糖尿病老年患者糖脂代谢影响:一项双盲随机对照研究

发布时间：2018-11-15 15:27

【摘要】：目的探讨富含n-3多不饱和脂肪酸的鱼油对老年2型糖尿病患者糖脂代谢的影响,为n-3多不饱和脂肪酸在2型糖尿病治疗中的应用提供科学依据。方法采用双盲随机对照的研究方法,将筛选的156名研究对象随机分成深海鱼油干预组和对照组,进行为期6月的双盲干预研究,探讨n-3多不饱和脂肪酸对糖脂代谢的影响。结果 3月后干预组的内脏脂肪等级较对照组显著减小(P=0.049),干预组血清甘油三酯水平显著低于对照组(P=0.019),高密度脂蛋白水平显著高于对照组(P=0.039),TG/HDL值显著低于对照组(P=0.007);6月后,干预组血清空腹胰岛素降低值显著高于对照组(P=0.043),干预组定量胰岛素敏感性指标数水平有一定程度的升高,但无统计学意义;干预组血清甘油三酯水平显著低于对照组(P=0.019),高密度脂蛋白水平显著高于对照组(P=0.004),TG/HDL值显著低于对照组(P=0.021)。结论 n-3多不饱和脂肪酸能调节2型糖尿病老年患者的脂代谢,对胰岛素敏感性和内脏肥胖有一定的改善作用。
[Abstract]:Objective to investigate the effect of fish oil rich in n-3 polyunsaturated fatty acids on glucose and lipid metabolism in elderly patients with type 2 diabetes, and to provide scientific basis for the application of n-3 polyunsaturated fatty acids in the treatment of type 2 diabetes. Methods 156 selected subjects were randomly divided into deep sea fish oil intervention group and control group for six months to investigate the effects of n-3 polyunsaturated fatty acids on glycolipid metabolism. Results after 3 months, the visceral fat grade in the intervention group was significantly lower than that in the control group (P0. 049), the serum triglyceride level in the intervention group was significantly lower than that in the control group (P0. 019), and the high density lipoprotein level in the intervention group was significantly higher than that in the control group (P0. 039). The TG/HDL value was significantly lower than that in the control group (P0. 007). After 6 months, the serum fasting insulin decreased in the intervention group was significantly higher than that in the control group (P0. 043). The quantitative insulin sensitivity index of the intervention group was increased to some extent, but there was no significant difference between the intervention group and the control group (P < 0. 043). The serum triglyceride level of intervention group was significantly lower than that of control group (P0. 019), the level of high density lipoprotein was significantly higher than that of control group (P0. 004), and the TG/HDL value of intervention group was significantly lower than that of control group (P0. 021). Conclusion n-3 polyunsaturated fatty acids can regulate lipid metabolism in elderly patients with type 2 diabetes mellitus and can improve insulin sensitivity and visceral obesity.
【作者单位】：东南大学公共卫生学院营养与食品卫生学系/环境医学工程教育部重点实验室;淮安市疾病预防控制中心;
【基金】：国家自然科学基金(No.81573144) 中国营养学会营养科研基金-帝斯曼专项科研基金项目
【分类号】：R587.1

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