宁夏回汉族人群转氨酶活性与代谢综合征相关性研究

发布时间：2018-11-22 14:54

【摘要】：目的探讨宁夏回汉人群血清中转氨酶活性与代谢综合征(metabolic syndrome,MS)及其相关指标的关系。方法采用病例-对照研究方法,2011年10月—2012年10月期间在宁夏医科大学附属医院及吴忠市人民医院进行定期健康体检人群中,筛选出877例无血缘关系的代谢综合征患者为病例组和655名无血缘关系的健康人为对照组。通过问卷方式调查研究对象的一般情况、生活方式、疾病及用药史、家族史等情况,通过体格检查测量研究对象的身高、体重、腰围、臀围及血压等。采集空腹静脉血进行实验室生化指标检测,包括空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)等。采用χ2检验、t检验和方差分析研究指标与MS患病的关系。结果病例组AST和ALT平均水平(t=-3.971,t=-6.048,P0.01)及异常率(χ2=11.556,χ2=33.231,P0.01)均高于对照组,差异有统计学意义。以对照组人群AST、ALT水平的75%以及40 U/L为界将研究对象分为低、中、高三组,调整性别、年龄、民族、文化程度、吸烟、饮酒等因素后,AST、ALT中水平人群MS患病风险分别是低水平人群的1.663倍(95%CI 1.263~2.189)和2.126倍(95%CI 1.586~2.852),高水平人群是低水平人群的2.801倍(95%CI 1.696~4.624)和4.918倍(95%CI 2.980~8.116),高水平人群是低水平+中水平人群的2.517倍(95%CI 1.530~4.142)和4.194倍(95%CI 2.554~6.885)。随着代谢综合征组分数量的增加,AST和ALT平均水平逐渐增加,差异均有统计学意义(F=7.742,F=11.753,P0.01)。不同年龄组间AST和ALT平均水平除对照组外,其余组间差异均有统计学意义(P0.05)。回族AST和ALT平均水平虽高于汉族,但差异均无统计学意义。男性AST、ALT平均水平均明显高于女性,除病例组AST水平外,其余组别差异均有统计学意义(P0.01)。不同BMI水平间AST和ALT平均水平差异均有统计学意义(P0.05)。结论 AST、ALT平均水平与MS的患病密切相关,正常范围内AST、ALT水平的偏高即可增加MS的患病风险,异常增高者MS患病风险的增加更为显著。AST、ALT水平可能成为预测MS患病、综合评价MS危险因素以及MS进展情况的重要因子。
[Abstract]:Objective to investigate the relationship between serum aminotransferase activity and metabolic syndrome (metabolic syndrome,MS). Methods from October 2011 to October 2012, a case-control study was conducted in the population of Ningxia Medical University affiliated Hospital and Wuzhong Municipal people's Hospital. 877 unrelated metabolic syndrome patients were selected as case group and 655 unrelated healthy people as control group. The general condition, life style, disease and medication history, family history and so on were investigated by questionnaire. The height, weight, waist circumference, hip circumference and blood pressure were measured by physical examination. Fasting venous blood samples were collected for laboratory biochemical tests, including fasting blood glucose (FPG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). Aspartate aminotransferase (AST), alanine aminotransferase (ALT) et al. 蠂 2 test, t test and ANOVA were used to study the relationship between MS and MS. Results the average levels of AST and ALT in the case group were higher than those in the control group (t = 3.971) and abnormal rate (蠂 ~ 2 = 11.556, 蠂 ~ 2 = 33.231 / P0.01). The difference was statistically significant. The subjects were divided into three groups: low, middle and high, adjusted sex, age, nationality, education level, smoking, drinking, and so on. The subjects were divided into three groups: low, middle and high, adjusted for sex, age, nationality, education, smoking, drinking and so on. The risk of MS in the middle level of ALT was 1.663 times higher than that in the lower level (95%CI 1.263 2.189) and 2.126 times (95%CI 1.586 卤2.852), respectively. The high level population was 2.801 times as high as the low level group (95%CI 1.696 4.624) and 4.918 times (95%CI 2.980,8.116). The high level population was 2.517 times (95%CI 1.530) and 4.194 times (95%CI 2.554 ~ 6.885). The average levels of AST and ALT increased gradually with the increase of the number of components in metabolic syndrome, and the difference was statistically significant (FF7.742 FU 11.753 P0.01). The average levels of AST and ALT in different age groups were significantly different except the control group (P0.05). The average levels of AST and ALT in Hui nationality were higher than those in Han nationality, but the difference was not statistically significant. The average level of AST,ALT in male was significantly higher than that in female, except the AST level in the case group, there were significant differences in the other groups (P0.01). There were significant differences in AST and ALT between different BMI levels (P0.05). Conclusion the average level of AST,ALT is closely related to the prevalence of MS. The high level of AST,ALT in normal range can increase the risk of MS, and the risk of MS in patients with abnormal increase is more significant. The level of AST,ALT may be a predictor of MS. The risk factors of MS and the important factors of the progress of MS were comprehensively evaluated.
【作者单位】：宁夏医科大学公共卫生与管理学院;宁夏医科大学总医院内分泌科;
【基金】：国家自然科学基金(No.81160110)
【分类号】：R589

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