阿司匹林治疗绝经后骨质疏松症的实验研究进展

发布时间：2018-12-13 01:10

【摘要】：综述阿司匹林治疗绝经后骨质疏松的实验研究进展,简要介绍阿司匹林的特性及在临床上的应用,以及阿司匹林治疗骨质疏松的机制,为治疗骨质疏松提供一种新的方法。以在体实验和离体实验作为文献的基本分类标准,进一步以各项实验室检测指标作为细化分类,广泛查阅近年来国内外有关阿司匹林治疗绝经后骨质疏松实验的相关文献,并综合分析。在体实验方面,分别从骨密度、骨组织形态学、骨生物力学、骨代谢生化指标等方面进行阐述;离体实验方面,整理阿司匹林治疗绝经后骨质疏松相关机制的信号通路、细胞因子表达及相关基因表达的实验研究进展。在此基础上做出总结,指出目前研究尚存在的问题,主要包括阿司匹林治疗绝经后骨质疏松症作用机理未完全阐明,以及相关流行病学研究的匮乏;提出下一步探究的思路,以期为相关研究者提供借鉴与参考。
[Abstract]:This paper reviews the experimental research progress of aspirin in the treatment of postmenopausal osteoporosis, briefly introduces the characteristics of aspirin and its clinical application, and the mechanism of aspirin in treating osteoporosis, which provides a new method for the treatment of osteoporosis. The in vivo and in vitro experiments were taken as the basic classification criteria, and the laboratory test indexes were further used as the detailed classification criteria. The relevant literature on aspirin treatment of postmenopausal osteoporosis was extensively reviewed in recent years. And comprehensive analysis. In vivo experiments, bone mineral density, bone histomorphology, bone biomechanics, biochemical indicators of bone metabolism, etc. In vitro, the signal pathway, cytokine expression and related gene expression in the treatment of postmenopausal osteoporosis with aspirin were reviewed. On the basis of this, the author points out the problems existing in the current research, mainly including the mechanism of aspirin in the treatment of postmenopausal osteoporosis is not fully clarified, and the lack of related epidemiological studies. To provide reference and reference for related researchers.
【作者单位】：第四军医大学西京医院骨科;
【基金】：国家自然科学基金(81270959)
【分类号】：R580

【参考文献】