糖尿病患者1,5-脱水葡萄糖醇、糖化血清蛋白、血糖、糖化血红蛋白与胰岛素水平相关性及其诊断价值

发布时间：2018-12-13 01:53

【摘要】：目的探讨糖尿病患者1,5-脱水葡萄糖醇(AG)、糖化血清蛋白(GSP)、血糖(Glu)、糖化血红蛋白(HbA1c)与胰岛素水平相关性及其诊断价值。方法利用生化检测法、发光免疫检测法,检测30例确诊(按照WHO标准)为糖尿病的患者的1,5-AG、GSP、Glu、HbA1c及胰岛素水平,将其设为观察组;并且以同样的方法检测30例正常健康者的1,5-AG、GSP、Glu、HbA1c及胰岛素水平,将其设为对照组,观察比较这两组患者中检验项目的差别,总结彼此之间的相关性以及对糖尿病临床诊断所起到的作用。结果观察组患者的GSP、1,5-AG、HbA1c以及胰岛素水平明显高于对照组(P0.05);观察组患者的Glu检测水平明显低于对照组;糖尿病患者Glu与GSP、1,5-AG、HbA1c及胰岛素之间均呈负相关。结论糖尿病患者1,5-AG、GSP、Glu、HbA1c及胰岛素之间具有较好的相关性,对糖尿病临床诊断具有重要的指导意义,能够真实、客观地反映出病变情况。
[Abstract]:Objective to investigate the relationship between insulin level and serum (GSP), glycosylated hemoglobin (HbA1c) and insulin level in patients with diabetes mellitus (DM). Methods the levels of HbA1c and insulin in 30 patients with diabetes mellitus (according to WHO standard) were detected by biochemical assay and luminescence immunoassay. The levels of HbA1c and HbA1c in Glu-GSPN of 30 normal controls were measured with the same method, and the difference of test items between the two groups was observed and compared. To summarize the correlation between each other and the role of diabetes in clinical diagnosis. Results the levels of GSP,1,5-AG,HbA1c and insulin in the observation group were significantly higher than those in the control group (P0.05), and the Glu levels in the observation group were significantly lower than those in the control group. There was a negative correlation between Glu, GSP,1,5-AG,HbA1c and insulin in diabetic patients. Conclusion there is a good correlation between HbA1c and insulin in patients with diabetes mellitus. It has important guiding significance for the clinical diagnosis of diabetes, and can reflect the pathological changes objectively and truly.
【作者单位】：重庆医科大学附属永川医院;
【基金】：国家高技术研究发展计划(863计划)基金资助(2011AA02A111)
【分类号】：R587.1

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