氯解磷定不同用药方案对急性重度有机磷中毒的疗效比较

发布时间：2018-12-13 03:33

【摘要】：筛选急性重度有机磷中毒患者195例,根据氯解磷定用药方案不同分成持续静滴治疗组和冲击治疗组,比较2组患者治疗情况。结果显示,与持续静滴治疗组比较,冲击治疗组死亡率显著增高;机械通气比例和入院4 h后新增机械通气比例均显著升高、机械通气时间显著延长(P0.05);持续静滴治疗组较冲击治疗组阿托品用量显著减少(P0.05);而氯解磷定用量及胆碱酯酶活性动态变化2组比较无统计学差异(P0.05)。持续静滴治疗组疗效明显优于冲击治疗组。
[Abstract]:195 patients with acute severe organophosphorus poisoning were selected and divided into continuous intravenous drip group and impulse therapy group. The results showed that compared with the continuous intravenous drip group, the mortality rate of the shock treatment group was significantly higher, the ratio of mechanical ventilation and the proportion of new mechanical ventilation were significantly increased, and the mechanical ventilation time was significantly prolonged (P0.05). The dosage of atropine in the continuous intravenous drip group was significantly lower than that in the impact treatment group (P0.05), while there was no significant difference between the two groups in the dosage of chlorophosphoridine and the dynamic change of cholinesterase activity (P0.05). The curative effect of continuous intravenous drip group was better than that of impact therapy group.
【作者单位】：中国医科大学附属第一医院急诊科;
【分类号】：R595.4

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