重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义

发布时间：2018-12-13 17:52

【摘要】：目的:检测糖尿病足(DF)患者血清中胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白3(IGFBP-3)和血浆蛋白的水平,探讨重组人生长激素(rhGH)对DF患者的治疗作用。方法:选取DF患者(DF组,n=40)、糖尿病患者(DM组,n=40)和健康成年人(正常对照组,n=40)为研究对象。将DF组患者按照患者意愿分为rhGH治疗组和常规治疗组,每组各20例。rhGH治疗组患者给予0.4IU·kg-1·d-1rhGH注射液,皮下注射,每个疗程15d,2个疗程间隔5d,总计3个疗程;常规治疗组患者给予同等剂量生理盐水皮下注射。比较各组研究对象一般临床资料、治疗前后血清IGF-1和IGFBP-3水平、患者病情分级构成、血浆蛋白总蛋白(TP)、转铁蛋白(TRF)、空腹血糖(FBG)水平及DF组患者和正常对照组研究对象rhGH治疗有效率和创面愈合时间。结果:DF组患者血清IGF-1和IGFBP-3水平明显低于DM组和正常对照组(P0.01);DM组患者血清IGF-1和IGFBP-3水平明显低于正常对照组(P0.05)。rhGH治疗组患者治疗后血清IGF-1、IGFBP-3和血浆TP、TRF水平与治疗前比较差异有统计学意义(P0.05),且均高于常规治疗组治疗后的相应指标(P0.05);DM组和正常对照组研究对象FBG水平比较差异无统计学意义(P0.05)。rhGH治疗组患者有效率明显高于常规治疗组(P0.05)。结论:DF患者经rhGH治疗后有效率提高,适合临床推广。
[Abstract]:Objective: to detect the levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and plasma protein in (DF) patients with diabetic foot. To investigate the therapeutic effect of recombinant human growth hormone (rhGH) on patients with DF. Methods: DF patients (DF group, n = 40), diabetic patients (DM group, n = 40) and healthy adults (normal control group, n = 40) were selected as subjects. The patients in the DF group were divided into two groups according to the wishes of the patients: the rhGH treatment group and the routine treatment group with 20 cases in each group. The patients in the rhGH treatment group were given 0.4IU kg-1 d-1rhGH injection subcutaneously for 15 days and the interval between the two courses was 5 days. A total of 3 courses of treatment; The patients in the routine treatment group were subcutaneously injected with the same dose of normal saline. The clinical data of each group were compared, the serum IGF-1 and IGFBP-3 levels before and after treatment, the grade composition of the patient's condition, the plasma total protein (TP), transferrin (TRF), were compared. Fasting blood glucose (FBG) level and the effective rate and wound healing time of rhGH in DF group and normal control group. Results: the levels of serum IGF-1 and IGFBP-3 in DF group were significantly lower than those in DM group and normal control group (P0.01). The levels of serum IGF-1 and IGFBP-3 in DM group were significantly lower than those in normal control group (P0.05). The levels of serum IGF-1,IGFBP-3 and plasma TP,TRF in DM group were significantly lower than those before treatment (P0.05). All of them were higher than the corresponding indexes of the routine treatment group (P0.05). There was no significant difference in FBG level between DM group and normal control group (P0.05). The effective rate of). RhGH group was significantly higher than that of routine treatment group (P0.05). Conclusion: the effective rate of DF patients is improved after rhGH treatment, which is suitable for clinical application.
【作者单位】：吉林省人民医院内分泌二科;
【基金】：吉林省科技厅科技发展计划项目资助课题(20130413006GH)
【分类号】：R587.2

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