血清超敏C-反应蛋白和降钙素原与D-二聚体及纤维蛋白原在糖尿病足感染患者中的变化分析

发布时间：2018-12-15 09:45

【摘要】：目的观察血清超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)、D-二聚体及纤维蛋白原在糖尿病足合并感染患者中的变化及其相关性,为糖尿病足感染的早期发现、早期预防提供参考。方法选取2014年5月-2016年5月糖尿病足患者159例,其中未感染患者71例,感染患者88例,其中轻度感染患者34例,中度感染患者33例,重度感染患者21例;采用免疫比浊法检测hs-CRP水平,酶联荧光分析检测PCT水平,全自动血凝分析仪检测纤维蛋白原、D-二聚体;比较各组患者hs-CRP、PCT、纤维蛋白原和D-二聚体水平差异。结果不同感染程度糖尿病足患者hs-CRP、PCT、纤维蛋白原和D-二聚体水平间存在显著性差异(P0.05);轻度感染组、中度感染组和重度感染组hs-CRP、PCT、纤维蛋白原和D-二聚体水平均明显高于未感染组,并且随着感染程度的加重水平不断升高;无效患者hs-CRP、PCT、纤维蛋白原和D-二聚体水平显著高于治愈患者、好转患者(P0.05);经Pearson检验,159例糖尿病足患者hs-CRP、PCT、纤维蛋白原和D-二聚体水平与患者性别、年龄以及糖尿病病程间均无相关性。血清炎性指标hs-CRP、PCT与纤溶指标纤维蛋白原和D-二聚体间存在显著相关性(P0.05)。结论炎症和纤溶指标在糖尿病足患者感染发展中发挥着重要作用,hs-CRP、PCT、纤维蛋白原和D-二聚体可用于反映糖尿病足感染程度及治疗情况。
[Abstract]:Objective to observe the changes of serum hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT), D-dimer and fibrinogen in patients with diabetic foot infection. Early prevention provides reference. Methods 159 cases of diabetic foot were selected from May 2014 to May 2016, including 71 cases of uninfected patients and 88 cases of infected patients, including 34 cases of mild infection, 33 cases of moderate infection and 21 cases of severe infection. The levels of hs-CRP, PCT, fibrinogen and D-dimer were detected by immunoturbidimetric assay, enzyme linked fluorescence assay and automatic hemagglutination analyzer respectively, and the difference of hs-CRP,PCT, fibrinogen and D-dimer levels were compared. Results there were significant differences in hs-CRP,PCT, fibrinogen and D-dimer levels between diabetic foot patients with different infection degree (P0.05). The levels of hs-CRP,PCT, fibrinogen and D-dimer in mild infection group, moderate infection group and severe infection group were significantly higher than those in non-infected group, and the level of hs-CRP,PCT, fibrinogen and D-dimer increased with the severity of infection. The levels of hs-CRP,PCT, fibrinogen and D-dimer in ineffective patients were significantly higher than those in cured patients (P0.05). By Pearson test, there was no correlation between hs-CRP,PCT, fibrinogen and D-dimer levels and sex, age and course of diabetes in 159 patients with diabetic foot. There was a significant correlation between serum inflammatory index hs-CRP,PCT and fibrinogen and D-dimer (P0.05). Conclusion inflammation and fibrinolysis play an important role in the development of diabetic foot infection. Hs-CRP,PCT, fibrinogen and D-dimer can be used to reflect the degree and treatment of diabetic foot infection.
【作者单位】：郑州人民医院内分泌科;
【分类号】：R587.2

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