护肝方治疗甲亢性肝损伤及对肝功能与甲状腺功能的影响

发布时间：2018-12-25 13:56

【摘要】：目的:探讨自拟护肝方治疗甲亢性肝损伤及对患者肝功能与甲状腺功能的影响。方法:选取医院内分泌科收治的130例甲亢性肝损伤患者为研究对象,随机分为两组,各65例。对照组:给予口服甲巯咪唑片及多烯磷脂酰胆碱胶囊治疗。观察组:在口服甲巯咪唑片及多烯磷脂酰胆碱胶囊治疗的基础上加用自拟护肝方治疗。分别检测肝功能、甲状腺激素及相关抗体、临床症状积分、甲状腺肿分级。结果:观察组总有效率89.23%高于对照组总有效率70.77%,差异具有统计学意义(P0.01)。治疗后,观察组患者血清ALT、AST、TBIL、ALP水平下降程度高于对照组(P0.01)。治疗后,两组患者血清FT3、FT4、TGAb、TPOAb水平均显著降低,TSH水平显著升高(P0.01);且观察组改善优于对照组(P0.01)。治疗后,观察组患者烦躁、心悸、多汗、震颤和多食症状积分均低于对照组(P0.01)。治疗后,观察组甲状腺肿分级正常率24.62%高于对照组甲状腺肿分级正常率10.77%,差异具有统计学意义(P0.05)。结论:自拟护肝方治疗甲亢性肝损伤可有效改善患者的肝功能和甲状腺功能。
[Abstract]:Objective: to investigate the effect of self-made recipe for protecting liver on hyperthyroidism liver injury and its effect on liver function and thyroid function in patients with hyperthyroidism. Methods: 130 patients with hyperthyroidism liver injury were randomly divided into two groups, 65 cases each. Control group: oral methimazole tablets and polyene phosphatidylcholine capsules were given. Observation group: on the basis of oral methimazole tablet and polyenylphosphatidylcholine capsule, self-made Hugan recipe was added. Liver function, thyroid hormone and related antibodies, clinical symptom score and goiter grade were detected. Results: the total effective rate of the observation group was 89.23% higher than that of the control group (70.77%), and the difference was statistically significant (P0.01). After treatment, the level of serum ALT,AST,TBIL,ALP in the observation group was lower than that in the control group (P0.01). After treatment, the serum FT3,FT4,TGAb,TPOAb level was significantly decreased and the TSH level was significantly increased in both groups (P0.01), and the improvement in the observation group was better than that in the control group (P0.01). After treatment, the scores of dysphoria, palpitation, sweating, tremor and eating symptoms in the observation group were lower than those in the control group (P0.01). After treatment, the normal rate of goiter grading in the observation group was 24.62% higher than that in the control group (10.77%). The difference was statistically significant (P0.05). Conclusion: the treatment of hyperthyroidism liver injury by self-prescription can improve the liver function and thyroid function of the patients.
【作者单位】：衢州市中医医院内分泌科;
【基金】：浙江省医药卫生科技计划项目(2014KYB304)
【分类号】：R581.1

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