系统性硬化症与红细胞分布宽度的相关性

发布时间：2019-01-05 15:18

【摘要】：目的探讨系统性硬化症(SSc)与红细胞分布宽度(RDW)的关系。方法回顾性分析2013年至2016年我院风湿免疫科就诊SSc患者。根据入院时RDW上、下四分位数(25%,75%)分为RDW低水平组(13.08%),RDW正常组(13.08%~14.93%),RDW高水平组(14.93%),比较3组一般资料、临床表现、超声心动图、心电图(ECG)、甲襞微循环(NCV)和其它实验室参数;所有统计学分析使用SPSS 17.0软件完成。结果SSc患者在RDW高水平组中,弥漫性硬皮病(46.7%)、关节炎(73.3%)、心脏受累(73.3%)、肺动脉高压(PAH)(53.3%)及肺间质病变(86.7%)比例均高于RDW正常组及RDW低水平组(P0.05);白蛋白(P=0.02)、血沉(ESR)(P=0.04)、CRP(P=0.01)、肺动脉收缩压(s PAP)(P=0.00)、NCV总积分(P=0.01)在RDW高水平组与RDW低水平组、RDW正常组间差异有统计学意义。RDW与白蛋白(r=0.36,P=0.00)、ESR(r=0.29,P=0.02)、CRP(r=0.37,P=0.00)、s PAP(r=0.34,P=0.00)呈正相关。ROC曲线分析RDW预测SSc继发PAH的结果显示,以14.95%为界值时获得相对较好的敏感度(0.67)和特异度(0.86)。结论 RDW与SSc广泛血管病变、纤维化及持续炎症密切相关,它的升高可一定程度上提示SSc合并心血管病变风险,或作为预测SSc继发肺动脉高压的有效指标。
[Abstract]:Objective to investigate the relationship between (SSc) and (RDW) in systemic sclerosis. Methods SSc patients from 2013 to 2016 were retrospectively analyzed. According to the RDW on admission, the lower quartile (25 / 75%) was divided into RDW low level group (13.08%), RDW normal group) (13.08% 14.93%), RDW high level group (14.93%). Echocardiography, (ECG), nailfold microcirculation (NCV) and other laboratory parameters. All statistical analysis was performed with SPSS 17.0 software. Results in the high level RDW group, SSc patients had diffuse scleroderma (46.7%), arthritis (73.3%), heart involvement (73.3%). The proportion of (PAH) (and interstitial lesion in pulmonary hypertension group (53.3%) and pulmonary interstitial disease group (86.7%) were higher than those in normal RDW group and low RDW group (P0.05). Albumin (P0. 02), erythrocyte sedimentation rate (ESR) (Pn0. 04), CRP (P0. 01), pulmonary arterial systolic blood pressure (PAP) (s PAP) (P0. 00), NCV (P0. 01) in RDW high level group and RDW low level group (P0. 01). There was significant difference in RDW between normal group and RDW and albumin (RDW 0.36), ESR (P0. 29), ESR (P0. 02), CRP (0. 37), s PAP (ru 0. 34, P 0. 34, P 0. 37, P 0. 37). ROC curve analysis showed that the relative sensitivity (0.67) and specificity (0.86) were obtained when the threshold value of SSc was 14.95%. Conclusion RDW is closely associated with extensive vascular lesions, fibrosis and persistent inflammation of SSc, and its elevation may suggest that SSc may be associated with the risk of cardiovascular disease to some extent, or as an effective indicator for predicting pulmonary hypertension secondary to SSc.
【作者单位】：西南医科大学附属医院风湿免疫科;
【分类号】：R593.2

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