糖皮质激素诱导小鼠骨质疏松模型构建方法的研究进展

发布时间：2019-01-06 10:10

【摘要】：糖皮质激素是由肾上腺皮质束状带分泌的一类甾体类激素,也可由化学方法人工合成,具有调节糖、脂肪和蛋白质合成和代谢的作用,还具有抑制免疫应答、抗炎、抗毒、抗休克的作用。但长时间应用糖皮质激素会导致骨量下降,甚至严重的骨质疏松,大大增加了骨折的风险。因此,针对激素诱导骨质疏松机制及治疗的探索显得愈发重要。目前,根据给药方式的不同,激素诱导小鼠骨质疏松模型的构建方法主要有植入缓释药物法,口服法和注射法三种。由于任何一种模型都只能与人体骨质疏松的临床表现部分相似,不能完全模拟人体骨质疏松的病理变化,因此每一种构建模型的方法都有其独特的适应面。现有研究表明,激素诱导骨质疏松模型的构建主要是通过调节内分泌,促进骨吸收和抑制成骨细胞,减少骨生成实现的。与其他动物相比,小鼠具有基因组与人类高度同源,近交突变系发达,基因修饰技术成熟,经济实惠等优点,因此,激素诱导的小鼠骨质疏松模型在骨质疏松研究工作中具有非常重要的意义。本文将对激素诱导小鼠骨质疏松模型的构建方法进行综述。
[Abstract]:Glucocorticoids are a class of steroidal hormones secreted by the adrenal cortical bundles. They can also be synthesized by chemical methods and can regulate the synthesis and metabolism of sugar, fat and protein. Antishock effect. But prolonged use of glucocorticoids leads to a decline in bone mass and even severe osteoporosis, significantly increasing the risk of fracture. Therefore, it is more and more important to explore the mechanism and treatment of hormone induced osteoporosis. At present, according to the different ways of administration, there are three main methods to construct the model of osteoporosis induced by hormone: implantable sustained-release method, oral method and injection method. Because any model can only be similar to the clinical manifestations of human osteoporosis, it can not completely simulate the pathological changes of human osteoporosis, so each method of model building has its own unique adaptation. Current studies have shown that hormone induced osteoporosis model construction is mainly through the regulation of endocrine, promote bone resorption and inhibit osteoblasts, and reduce bone formation. Compared with other animals, mice have the advantages of highly homologous genomes with human beings, developed inbred mutants, mature genetic modification techniques, and economic benefits. Hormone-induced osteoporosis model in mice is of great significance in the study of osteoporosis. In this paper, the methods of constructing the model of osteoporosis induced by hormone in mice are reviewed.
【作者单位】：第二军医大学附属长海医院学员管理大队;第二军医大学海医四队;第二军医大学附属长海医院创伤骨科;中韩生物医学工程中心;
【分类号】：R-332;R580

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