无症状高尿酸血症大鼠血液流变学和氧化应激

发布时间：2019-01-21 10:24

【摘要】：目的从血液流变学的角度对长期无症状高尿酸血症开展系统研究,为该症的临床处理提供参考依据。方法将20只SD大鼠随机平均分为空白对照组和模型组。通过对大鼠腹腔注射250 mg/(kg·d)氧嗪酸钾诱导8周无症状高尿酸血症模型,采血测量尿酸水平、血液流变学指标、氧化和抗氧化指标。结果模型组大鼠红细胞的聚集指数、破碎率、血清黄嘌呤氧化酶活性(XOD)、血浆纤维蛋白原、血液黏度显著升高,红细胞的取向指数、电泳率、血清超氧化物歧化酶活性(SOD)、活化部分凝血酶时间(APTT)和凝血酶原时间(PT)显著降低。结论无症状高尿酸血症水平下机体氧化应激增强,使大鼠红细胞流变特性发生不良变化,血液处于高黏高凝状态。研究结果提示临床诊治中应对无症状高尿酸血症正确认识并及时干预。
[Abstract]:Objective to systematically study chronic asymptomatic hyperuricemia from the perspective of hemorheology, and to provide reference for clinical management of the disease. Methods 20 SD rats were randomly divided into blank control group and model group. The model of asymptomatic hyperuricemia was induced by intraperitoneal injection of potassium oxazinate for 8 weeks. The levels of uric acid, hemorheology, oxidation and antioxidation were measured. Results in the model group, the aggregation index, fragmentation rate, serum xanthine oxidase activity, plasma fibrinogen, blood viscosity, erythrocyte orientation index and electrophoretic rate were significantly increased. The activity of serum superoxide dismutase (SOD),) activated partial thrombin time (APTT) and prothrombin time (PT) significantly decreased. Conclusion oxidative stress is enhanced under asymptomatic hyperuricemia, which results in adverse changes of erythrocyte rheological characteristics and hyperviscosity and hypercoagulability. The results suggest that the correct understanding of asymptomatic hyperuricemia and timely intervention should be taken in clinical diagnosis and treatment.
【作者单位】：承德医学院血液流变学研究室;河北大学附属医院麻醉科;
【基金】：河北省高等学校科学技术研究项目(QN20131033) 承德医学院自然科学重点课题(201709)
【分类号】：R589.7

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