干细胞移植联合活血生肌汤治疗糖尿病足伴下肢慢性缺血的疗效

发布时间：2019-01-23 20:59

【摘要】：目的探讨干细胞移植联合活血生肌汤治疗糖尿病足(DF)伴下肢慢性缺血的疗效。方法 90例DF伴下肢慢性缺血患者随机分成常规组(常规治疗组)、干细胞组(干细胞移植+常规治疗)和综合组(干细胞移植+活血生肌汤+常规治疗)各30例,均治疗12 w。比较治疗前后各组的间接性跛行评分、皮肤温度、裸臂指数(ABI)、疼痛评分、糖化血红蛋白(Hb A1c)水平以及溃疡面积和深度变化情况,并观察各组疗效情况。结果与治疗前相比,干细胞组和综合组治疗后间接性跛行评分、疼痛评分均显著降低,ABI、皮肤温度均显著增加(P0.05)。治疗后间接性跛行评分、疼痛评分常规组干细胞组综合组,两两比较差异均有统计学意义(P0.05),而ABI、皮肤温度均常规组干细胞组综合组,两两比较差异均有统计学意义(P0.05)。3组Hb A1c比较无统计学差异(P0.05)。治疗后干细胞、综合组溃疡面积和深度均降低,且常规组干细胞组综合组,两两比较差异均有统计学意义(P0.05)。治疗后干细胞组、综合组的总有效率均明显优于常规组(P0.05)。结论干细胞移植技术是治疗DF伴下肢慢性缺血的有效方法,与中药合用可以提高干细胞移植技术的疗效。
[Abstract]:Objective to investigate the effect of stem cell transplantation combined with Huoxue Shengji decoction on diabetic foot (DF) with lower limb chronic ischemia. Methods 90 DF patients with chronic lower limb ischemia were randomly divided into conventional group, stem cell group (stem cell transplantation routine treatment) and comprehensive group (stem cell transplantation Huoxue Shengji decoction routine treatment) for 12 weeks. Indirect claudication score, skin temperature, bare arm index (ABI),) pain score, Hb A1c level, ulcer area and depth were compared before and after treatment. Results compared with before treatment, the scores of indirect claudication and pain in stem cell group and comprehensive group were significantly decreased, and the skin temperature of ABI, was significantly increased (P0.05). After treatment, the score of indirect claudication and pain score were significantly different between the two groups (P0.05), while the skin temperature of ABI, was normal stem cell group (P05). The differences were statistically significant (P0.05). There was no significant difference in Hb A1c among the 3 groups (P0.05). After treatment, the area and depth of ulcer were decreased in the comprehensive group, and the difference between the two groups was statistically significant (P0.05). After treatment, the total effective rate of stem cell group and comprehensive group were significantly better than that of routine group (P0.05). Conclusion Stem cell transplantation is an effective method for the treatment of DF with chronic ischemia of lower extremity.
【作者单位】：黄河科技学院;
【基金】：河南省科技攻关重点项目(No.152102310170)
【分类号】：R587.2

【相似文献】