糖尿病家族史和肥胖对高血糖发病的联合作用

发布时间：2019-02-23 22:51

【摘要】：目的探讨南京社区居民糖尿病家族史和肥胖对高血糖发病的联合作用。方法采用多阶段分层整群抽样的方法,对30岁及以上的居民进行调查。符合条件的调查对象共3 376名,剔除已确诊的高血糖患者(476例),最终纳入2 900例非高血糖的人群作为基线样本,3年后开展随访调查。应用Cox回归模型分析糖尿病家族史与肥胖的联合作用对高血糖发生的风险比。结果 3年后共随访2 093名调查对象,随访率为72.2%。高血糖3年累计发病率为7.5%;无糖尿病家族史/无肥胖组累计发病率最低(6.4%),有糖尿病家族史/肥胖组最高(13.3%)。多因素Cox回归分析显示,与无糖尿病家族史/无肥胖组相比,有糖尿病家族史/无肥胖组、有糖尿病家族史/肥胖组发生高血糖是其1.63倍(HR=1.63,95%CI:1.02~2.60,P=0.042)和2.37倍(HR=2.37,95%CI:1.36~4.13,P=0.002);有糖尿病家族史/有肥胖组发生高血糖风险最高。结论糖尿病家族史和肥胖共存会增加高血糖发病风险,提示具有糖尿病家族史的人群控制体重有利于高血糖的预防。
[Abstract]:Objective to explore the combined effect of diabetes family history and obesity on hyperglycemia in community residents in Nanjing. Methods Multi-stage stratified cluster sampling was used to investigate residents aged 30 and above. A total of 3 376 eligible subjects were selected, including 476 confirmed hyperglycemia patients, and 2 900 non-hyperglycemic subjects as baseline samples. A follow-up survey was conducted 3 years later. Cox regression model was used to analyze the risk ratio of diabetes family history and obesity to hyperglycemia. Results A total of 2 093 subjects were followed up 3 years later, the follow-up rate was 72. 2%. The cumulative incidence of hyperglycemia in 3 years was 7.5, and the cumulative incidence of diabetes was the lowest (6.4%) in the non-diabetic family / obesity group, and the highest (13.3%) in the diabetic family history / obesity group. Multivariate Cox regression analysis showed that the incidence of hyperglycemia was 1.63 times higher in the diabetic family history / obesity group than in the non-diabetic family history / obesity group (HR=1.63,95%CI:1.02~2.60,). (P < 0.01) and 2.37 times (HR=2.37,95%CI:1.36~4.13,P=0.002); The family history of diabetes / obesity group had the highest risk of hyperglycemia. Conclusion the coexistence of family history of diabetes and obesity may increase the risk of hyperglycemia, which suggests that weight control is beneficial to the prevention of hyperglycemia in people with family history of diabetes.
【作者单位】：南京市疾病预防控制中心慢性非传染性疾病防制科;
【基金】：2014年度南京市医学科技发展项目(YKK14165)
【分类号】：R587.1

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