复旦大学发现机体能量代谢和肥胖调控新机制
发布时间：2019-03-01 12:14
【摘要】：正复旦大学吴晓晖课题组利用piggy Bac转座子插入突变小鼠资源,发现了G蛋白偶联受体GPR45在肥胖发生发展中的重要作用,并阐明了GPR45调控阿黑皮素原(POMC)表达及机体能量代谢的分子机制。相关成果日前发表于《临床研究杂志》。研究人员利用piggy Bac转座子插入诱变小鼠资源筛选体重和体脂含量异常的基因突变,从408个基因突变品
[Abstract]:Wu Xiaohui of ZhengFudan University used piggy Bac transposons to insert mutated mouse resources, and found that G protein-coupled receptor GPR45 plays an important role in the occurrence and development of obesity. The molecular mechanism of the regulation of pro-(POMC) expression and energy metabolism by GPR45 was also elucidated. The results were published in the Journal of Clinical Research. The researchers used piggy Bac transposon insertion mutagenesis resources to screen gene mutations with abnormal body weight and body fat content from 408 mutants.
【分类号】：R589.2
本文编号：2432417
[Abstract]:Wu Xiaohui of ZhengFudan University used piggy Bac transposons to insert mutated mouse resources, and found that G protein-coupled receptor GPR45 plays an important role in the occurrence and development of obesity. The molecular mechanism of the regulation of pro-(POMC) expression and energy metabolism by GPR45 was also elucidated. The results were published in the Journal of Clinical Research. The researchers used piggy Bac transposon insertion mutagenesis resources to screen gene mutations with abnormal body weight and body fat content from 408 mutants.
【分类号】：R589.2
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