2型糖尿病合并骨质疏松患者维生素D水平及其危险因素

发布时间：2019-03-18 15:14

【摘要】：目的探讨2型糖尿病(T2DM)合并骨质疏松(OP)患者血清维生素D(VD)水平及发生OP的危险因素。方法选取2010年1月至2015年6月在该院内分泌科住院治疗的133例T2DM合并OP患者为病例组,同时选取同期住院的133例单纯T2DM患者为对照组。对两组患者血清25羟VD〔25(OH)VD〕、空腹血糖、糖化血红蛋白、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯水平进行对比分析,并对两组患者进行OP危险因素的调查分析。结果病例组患者血清25(OH)VD水平低于对照组,男性患者高于女性患者(P0.05);女性患者中血清25(OH)VD水平与糖化血红蛋白呈负相关(P0.05)。多因素Logistic回归分析发现,T2DM患者发生OP的危险因素有年龄(OR=2.152)、性别(OR=2.275)、糖尿病病程(OR=2.251)、体重指数(BMI)(OR=2.232)、空腹血糖(OR=2.118)、糖化血红蛋白(OR=2.179)。结论 T2DM合并OP患者较单纯糖尿病患者VD缺乏更严重。高龄、女性、糖尿病病程较长、低BMI、血糖控制不好的T2DM患者发生OP的危险性更高,提示T2DM患者在控制血糖的同时,应对高危人群的骨密度异常进行早期诊断、早期干预,降低OP发生率,提高T2DM患者的生存质量。
[Abstract]:Objective To study the level of serum vitamin D (VD) and the risk factors of OP in patients with type 2 diabetes mellitus (T2DM) combined with osteoporosis (OP). Methods 133 patients with T2DM who were hospitalized in the endocrinology department of the hospital from January 2010 to June 2015 were selected as the case group, and 133 patients with T2DM in the same period were selected as the control group. Serum 25-hydroxyVD-25 (OH) VD, fasting blood glucose, glycosylated hemoglobin, high-density lipoprotein, low-density lipoprotein, total cholesterol and triglyceride were compared and analyzed in two groups. Results The level of serum 25 (OH) VD in the case group was lower than that of the control group (P <0.05). The serum 25 (OH) VD level in the female patients was negatively correlated with the glycosylated hemoglobin (P0.05). The multivariate logistic regression analysis found that the risk factors of OP in patients with T2DM were age (OR = 2.152), sex (OR = 2.275), course of diabetes (OR = 2.251), body mass index (BMI) (OR = 2.232), fasting blood glucose (OR = 2.118), and glycosylated hemoglobin (OR = 2.179). Conclusion The deficiency of VD in patients with T2DM with OP is more serious than that of patients with simple diabetes. The risk of OP is higher in patients with T2DM, such as advanced age, female, diabetic course, low BMI, and poor blood glucose control. Improve the quality of life of patients with T2DM.
【作者单位】：北京市第二医院内科;首都医科大学附属北京天坛医院内分泌科;
【分类号】：R587.1;R580

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