糖脉康颗粒联合阿仑膦酸钠片治疗糖尿病合并骨质疏松症的临床研究
发布时间：2019-03-27 12:36
【摘要】：目的探讨糖尿病与骨质疏松症的关系,加强对糖尿病合并骨质疏松症的认识,通过临床观察糖脉康颗粒联合阿仑膦酸钠片治疗2型糖尿病合并骨质疏松症患者的客观指标评价其临床疗效及安全性,为临床应用提供客观依据,更好服务于临床。方法选取2012年10月至2014年3月期间于就诊于武汉市中西结合医院内分泌科门诊及住院部的2型糖尿病合并骨质疏松症的患者,按照纳入条件选取60例,随机分为两组,分别为对照组和观察组。在饮食、运动的基础治疗和糖尿病常规降糖治疗的基础上,对照组给予阿仑膦酸钠片(石家庄制药集团欧意药业有限公司),每日一片(10mg),早晨空腹口服,治疗组在观察组的基础上加用糖脉康颗粒(成都中汇制药有限公司),每日三次,1次1包(5 g)。两组在治疗期间均补充维生素和钙剂。两组均连续服用6个月。观察两组治疗前后中医临床症状积分,空腹血糖(FPG),餐后血糖(2h PG),糖化血红蛋白(Hb A1c),骨密度测定(BMD)等进行统计分析。将所得数据应用SPSS17.0统计软件进行统计学分析,其中多组间的数据两两比较用t检验,疗效的百分率的比较用χ2检验。此外,监测患者血、尿、粪及肝肾功能等常规指标,了解药物的安全性。结果①两组剔除率比较:对照组与观察组均未出现剔除情况,表明糖脉康颗粒为中药浓缩颗粒冲剂,服用方便,使患者具有良好的依从性。②中医症状临床积分比较:治疗前两组患者在症状和体征的总积分上均无显著性差异(P0.05),治疗后两组症候总积分均改善(P0.05)。同时应用尼莫地平法对各个中医症候疗效比较发现,观察组患者在倦怠乏力、气短懒言、口干喜饮、手足心热、自汗盗汗、舌苔脉象症状上得到明显改善,总有效率大于对照组,差异有非常显著性统计学意义(P0.01),在腰膝酸软、腰背疼痛上也较对照组改善明显,有显著性差异(P0.05)。③骨密度值的比较:治疗前两组骨密度值无明显差异(P0.05),治疗后两组较治疗前有显著性差异(P0.05),同时对照组与观察组比较也显著性差异(P0.05)。④血糖值的比较:治疗前两组在空腹血糖、餐后血糖、糖化血红蛋白均无显著性差异(P0.05),治疗后两组血糖水平较治疗前均有明显改善,FPG、2h PG、Hb A1c较治疗前有显著性差异(P0.05),但两组间治疗后比较无显著性差异(P0.05),提示患者血糖均得到有效控制,但两组降糖效果相近。⑤不良反应监测情况的比较:两组患者治疗前后血常规、肝功能和肾功能均无明显异常。对照组出现上腹部不适1例,但可耐受,观察组未见明显不适,两组均未见严重不良反应发生。结论通过本研究发现应用糖脉康颗粒联合阿仑膦酸钠片治疗糖尿病合并骨质疏松症的不仅能显著改善患者中医症候,而且可以提高骨密度,控制血糖水平。同时糖脉康颗粒是传统中药浓缩颗粒冲剂,具有服用方便的优点,并且无明显的不良反应和毒副作用,在糖尿病合并骨质疏松症患者中值得推广。
[Abstract]:Objective To study the relationship between diabetes and osteoporosis and to strengthen the understanding of diabetes and osteoporosis. Provides an objective basis for clinical application and better service for clinical application. Methods From October,2012 to March,2014, the patients with type 2 diabetes and osteoporosis who were treated in the Department of the Endocrinology Department of Wuhan and the Chinese and Western combined hospital and the residents were randomly divided into two groups according to the conditions of inclusion, and the control group and the observation group were randomly divided into two groups. On the basis of the basic treatment of diet and exercise and the conventional blood sugar-lowering treatment of diabetes, the control group was given an Alphalan sodium tablet (Shijiazhuang Pharmaceutical Group, Oyi Pharmaceutical Co., Ltd.), one tablet daily (10 mg), and oral in the morning. On the basis of the observation group, the treatment group was treated with Tanggukang granule (Chengdu Zhonghui Pharmaceutical Co., Ltd.) three times a day and 1 bag (5 g). Both groups were supplemented with vitamins and calcium in the course of the treatment. The two groups were taken for 6 months. The clinical symptoms, fasting blood glucose (FPG), postprandial blood sugar (2h PG), glycosylated hemoglobin (Hb), bone mineral density (BMD), and the like of the two groups before and after treatment were statistically analyzed. Statistical analysis of the obtained data was carried out using the SPSS17.0 statistical software. The data between the multiple groups were compared with t-test, and the percentage of the curative effect was compared with the other two. In addition, routine indexes such as blood, urine, feces and liver and kidney function of the patient are monitored to understand the safety of the medicine. Results Compared with the two groups, the control group and the observation group had no rejection, which indicated that the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which is convenient to take, and the patient has good compliance. There was no significant difference in the total scores of symptoms and signs in the first two groups (P0.05), and the total score of the two groups was improved after treatment (P0.05). At the same time, the curative effect of the nimodipine on the symptoms of various Chinese medicine is found, and the patients in the observation group have a marked improvement in the symptoms of listlessness, fatigue, short-time, dry-mouth and dry-up, hand-and-foot-heart heat, spontaneous perspiration and night sweat, and tongue and tongue coating, and the total effective rate is greater than that of the control group. The difference was significant (P0.01). There was a significant difference in the soft and back pain of the waist and knees (P0.05). The values of bone mineral density in the two groups were not significant (P0.05). There was a significant difference between the two groups after the treatment (P0.05), and the control group and the observation group were significantly different (P0.05). The results showed that the two groups had no significant difference in fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin (P0.05). After treatment, the blood glucose levels in the two groups were significantly improved, and the FPG, 2h PG and Hb were significantly different before the treatment (P0.05). However, there was no significant difference between the two groups (P0.05). Comparison of the monitoring of the adverse reaction of the two groups: the blood routine, the liver function and the renal function were not obvious before and after the treatment of the two groups. The abdominal discomfort in the control group was 1 case, but it was tolerated. No obvious discomfort was found in the observation group, and no serious adverse reaction occurred in the two groups. Conclusion It is found that by this study, the combined treatment of diabetes and osteoporosis with the combination of Tanggukang granule and Alphalan sodium tablets not only can obviously improve the symptoms of the traditional Chinese medicine, but also can improve the bone mineral density and control the blood sugar level. At the same time, the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which has the advantages of convenient administration, no obvious adverse reaction and toxic and side effects, and is worthy of popularization in the patients with diabetes and osteoporosis.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R580
本文编号：2448185
[Abstract]:Objective To study the relationship between diabetes and osteoporosis and to strengthen the understanding of diabetes and osteoporosis. Provides an objective basis for clinical application and better service for clinical application. Methods From October,2012 to March,2014, the patients with type 2 diabetes and osteoporosis who were treated in the Department of the Endocrinology Department of Wuhan and the Chinese and Western combined hospital and the residents were randomly divided into two groups according to the conditions of inclusion, and the control group and the observation group were randomly divided into two groups. On the basis of the basic treatment of diet and exercise and the conventional blood sugar-lowering treatment of diabetes, the control group was given an Alphalan sodium tablet (Shijiazhuang Pharmaceutical Group, Oyi Pharmaceutical Co., Ltd.), one tablet daily (10 mg), and oral in the morning. On the basis of the observation group, the treatment group was treated with Tanggukang granule (Chengdu Zhonghui Pharmaceutical Co., Ltd.) three times a day and 1 bag (5 g). Both groups were supplemented with vitamins and calcium in the course of the treatment. The two groups were taken for 6 months. The clinical symptoms, fasting blood glucose (FPG), postprandial blood sugar (2h PG), glycosylated hemoglobin (Hb), bone mineral density (BMD), and the like of the two groups before and after treatment were statistically analyzed. Statistical analysis of the obtained data was carried out using the SPSS17.0 statistical software. The data between the multiple groups were compared with t-test, and the percentage of the curative effect was compared with the other two. In addition, routine indexes such as blood, urine, feces and liver and kidney function of the patient are monitored to understand the safety of the medicine. Results Compared with the two groups, the control group and the observation group had no rejection, which indicated that the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which is convenient to take, and the patient has good compliance. There was no significant difference in the total scores of symptoms and signs in the first two groups (P0.05), and the total score of the two groups was improved after treatment (P0.05). At the same time, the curative effect of the nimodipine on the symptoms of various Chinese medicine is found, and the patients in the observation group have a marked improvement in the symptoms of listlessness, fatigue, short-time, dry-mouth and dry-up, hand-and-foot-heart heat, spontaneous perspiration and night sweat, and tongue and tongue coating, and the total effective rate is greater than that of the control group. The difference was significant (P0.01). There was a significant difference in the soft and back pain of the waist and knees (P0.05). The values of bone mineral density in the two groups were not significant (P0.05). There was a significant difference between the two groups after the treatment (P0.05), and the control group and the observation group were significantly different (P0.05). The results showed that the two groups had no significant difference in fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin (P0.05). After treatment, the blood glucose levels in the two groups were significantly improved, and the FPG, 2h PG and Hb were significantly different before the treatment (P0.05). However, there was no significant difference between the two groups (P0.05). Comparison of the monitoring of the adverse reaction of the two groups: the blood routine, the liver function and the renal function were not obvious before and after the treatment of the two groups. The abdominal discomfort in the control group was 1 case, but it was tolerated. No obvious discomfort was found in the observation group, and no serious adverse reaction occurred in the two groups. Conclusion It is found that by this study, the combined treatment of diabetes and osteoporosis with the combination of Tanggukang granule and Alphalan sodium tablets not only can obviously improve the symptoms of the traditional Chinese medicine, but also can improve the bone mineral density and control the blood sugar level. At the same time, the sugar-pulse-kang granule is a traditional Chinese medicine concentrated granule, which has the advantages of convenient administration, no obvious adverse reaction and toxic and side effects, and is worthy of popularization in the patients with diabetes and osteoporosis.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R580
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