机械振动防治骨质疏松症的研究进展
发布时间：2019-04-03 12:34
【摘要】：骨质疏松症是最常见的骨骼疾病,以骨量丢失、骨的显微结构发生改变为特征,导致骨的脆性增加、易于骨折,严重影响患者生活质量,增加致残率及病死率,给家庭及社会造成沉重负担。随着老龄化社会的到来,骨质疏松症在人群中的发病率呈逐年上升的趋势。机械振动作为一种短期、简便、无创、不良反应少的物理疗法受到广泛关注。机械振动的成骨效应已在多项细胞和动物实验中得到验证,并获得临床试验的支持,但其作用机制尚不明确,现有骨传导、肌动力、骨血灌注、脂质代谢、压电效应等多种假说。机械振动有多种应用模式,包括局部或全身振动、垂直或复合振动、间歇或持续振动、单独或联合应用等,但目前在不同模式的疗效及选择上仍有争议。因此,了解机械振动在防治骨质疏松症领域的应用概况及各种振动模式的特点可为今后的科学研究和临床应用提供新的思路。
[Abstract]:Osteoporosis is the most common bone disease, characterized by loss of bone mass and changes in bone microstructure, resulting in increased fragility of bone, easy fracture, serious impact on the quality of life of patients, increased disability rate and mortality. Place a heavy burden on the family and society. With the arrival of aging society, the incidence of osteoporosis in the population is increasing year by year. Mechanical vibration as a short-term, simple, non-invasive, less adverse reaction physiotherapy has been widely concerned. The osteogenic effect of mechanical vibration has been verified in a number of cell and animal experiments, and has been supported by clinical trials, but its mechanism is still unclear, such as bone conduction, muscle dynamics, bone blood perfusion, lipid metabolism, and so on. Piezoelectric effect and other hypotheses. There are many application modes of mechanical vibration, including local or whole body vibration, vertical or compound vibration, intermittent or continuous vibration, single or combined application, but the curative effect and choice of different modes are still controversial. Therefore, understanding the application of mechanical vibration in the field of prevention and treatment of osteoporosis and the characteristics of various vibration modes can provide a new way of thinking for scientific research and clinical application in the future.
【作者单位】： 广州中医药大学第一临床医学院;广州中医药大学岭南医学研究中心中医骨伤科学实验室;广州中医药大学第一附属医院;
【基金】：国家自然科学基金资助项目(81473697,81673999) 广东省杰出青年科学基金资助项目(2015A030306037) 广东省中医药局何伟省名中医传承工作室建设项目(粤中医办函(2017)17号) 广东省科技计划项目(2014A020221041) 广东省医学科学技术研究基金项目(A2015039)
【分类号】：R580
本文编号：2453217
[Abstract]:Osteoporosis is the most common bone disease, characterized by loss of bone mass and changes in bone microstructure, resulting in increased fragility of bone, easy fracture, serious impact on the quality of life of patients, increased disability rate and mortality. Place a heavy burden on the family and society. With the arrival of aging society, the incidence of osteoporosis in the population is increasing year by year. Mechanical vibration as a short-term, simple, non-invasive, less adverse reaction physiotherapy has been widely concerned. The osteogenic effect of mechanical vibration has been verified in a number of cell and animal experiments, and has been supported by clinical trials, but its mechanism is still unclear, such as bone conduction, muscle dynamics, bone blood perfusion, lipid metabolism, and so on. Piezoelectric effect and other hypotheses. There are many application modes of mechanical vibration, including local or whole body vibration, vertical or compound vibration, intermittent or continuous vibration, single or combined application, but the curative effect and choice of different modes are still controversial. Therefore, understanding the application of mechanical vibration in the field of prevention and treatment of osteoporosis and the characteristics of various vibration modes can provide a new way of thinking for scientific research and clinical application in the future.
【作者单位】： 广州中医药大学第一临床医学院;广州中医药大学岭南医学研究中心中医骨伤科学实验室;广州中医药大学第一附属医院;
【基金】：国家自然科学基金资助项目(81473697,81673999) 广东省杰出青年科学基金资助项目(2015A030306037) 广东省中医药局何伟省名中医传承工作室建设项目(粤中医办函(2017)17号) 广东省科技计划项目(2014A020221041) 广东省医学科学技术研究基金项目(A2015039)
【分类号】：R580
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