奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响

发布时间：2019-04-03 17:54

【摘要】：目的:探讨奥美拉唑联合活血化瘀通络方对糖尿病胃轻瘫胃动力障碍疗效及相关指标的影响。方法:92例糖尿病胃轻瘫胃动力障碍患者随机均分为观察组和对照组。两组患者均给予糖尿病膳食指导与运动指导,对于合并代谢紊乱和高血压者给予调脂和降压等常规治疗。在此基础上,对照组患者口服奥美拉唑肠溶胶囊20 mg,每日1次;观察组患者在对照组治疗的基础上给予活血化瘀通络方水煎服,取汁300 ml,每次150 ml,每日2次。两组疗程均为14 d。观察两组患者的临床疗效,治疗前后空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、胃半排空时间(GET_(1/2))及不良反应发生情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P0.05)。治疗前,两组患者空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、GET_(1/2)比较,差异均无统计学意义(P0.05)。治疗后,两组患者空腹血糖、糖化血红蛋白、全血黏度、胃动素、胃泌素、GET_(1/2)均显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,奥美拉唑联合活血化瘀通络方治疗糖尿病胃轻瘫胃动力障碍的疗效显著优于单用奥美拉唑,可降低血糖,改善血流动力学,且安全性相当。
[Abstract]:Aim: to investigate the effect of omeprazole combined with Huoxue Huayu Tongluo recipe on gastric motility disorder in diabetic gastroparesis. Methods: 92 cases of diabetic gastroparesis with gastric motility disorder were randomly divided into observation group and control group. Two groups of patients were given diabetic dietary guidance and exercise guidance, the patients with metabolic disorders and hypertension were given routine treatment such as lipid regulation and hypotension. On the basis of this, the patients in the control group were given omeprazole enteric-coated capsules once a day for 20 mg, and the patients in the observation group were treated with the decoction of activating blood circulation and removing blood stasis and Tongluo decoction on the basis of the treatment of the control group, and the juice was taken for 300 ml, for 150 ml, twice a day. The course of treatment in both groups was 14 d. The clinical efficacy, fasting blood glucose, glycosylated hemoglobin, whole blood viscosity, motilin, gastrin, gastric half emptying time (GET_ (1 / 2) and side effects were observed before and after treatment. Results: the total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P0.05). Before treatment, there was no significant difference in fasting blood glucose, glycosylated hemoglobin, whole blood viscosity, motilin, gastrin and GET_ (1 / 2) between the two groups (P0.05). After treatment, fasting blood glucose, glycosylated hemoglobin, whole blood viscosity, motilin, gastrin and GET_ (1) in the two groups were significantly lower than those before treatment in the same group, and the observation group was lower than that in the control group (P0.05). No significant adverse reactions were observed in both groups during treatment. Conclusion: on the basis of routine treatment, omeprazole combined with Huoxue Huayu Tongluo decoction is superior to omeprazole alone in the treatment of diabetic gastroparesis gastric motility disorder. It can reduce blood sugar and improve hemodynamics, and the safety is equal.
【作者单位】：南阳市中心医院消化内科一病区;
【分类号】：R587.2

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