阿托伐他汀联合阿司匹林对绝经期冠心病妇女骨密度及骨生化和代谢的影响

发布时间：2019-04-09 17:59

【摘要】：目的观察阿托伐他汀联合阿司匹林对绝经期冠心病妇女骨密度及骨生化和代谢的影响。方法 60名绝经后冠心病患者,按随机数字表法将其分为治疗组(n=30)、及对照组(n=30)。对照组给予阿司匹林治疗,治疗组给予阿托伐他汀联合阿司匹林治疗,12个月。测定治疗不同时间段患者,腰椎1-4(L1-4)、股骨颈、股骨大转子及全髋BMD及血钙(Ca)、血磷(P)、血清1型前胶原N端前肽(P1NP)及1型胶原羧基端降解产物(β-CTX)水平的变化情况。结果治疗后6个月及12个月,两组患者的骨密度都有不同程度提高,治疗组腰椎1-4(L1-4)、股骨颈、股骨大转子及全髋骨密度均显著高于同时期对照组(P0.05);治疗后6个月及12个月,两组患者的血Ca、P、β-CTX及P1NP都有不同程度改变,血Ca、P、β-CTX较治疗前明显下降,P1NP明显上升(P0.05),而治疗组改变明显高于同期对照组(P0.05)。结论阿托伐他汀联合阿司匹林提升绝经期冠心病妇女患者骨密度,改善骨生化和代谢状态。
[Abstract]:Objective to observe the effects of Atto vastatin combined with aspirin on bone mineral density (BMD), bone biochemistry and metabolism in menopausal women with coronary heart disease (CHD). Methods Sixty postmenopausal patients with coronary heart disease were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). The control group was treated with aspirin and the treatment group was treated with Atto vastatin combined with aspirin for 12 months. The BMD of lumbar vertebra 1? 4 (L 1? 4), femoral neck, trochanteric trochanter and total hip, and serum calcium (Ca), and serum phosphorus (P), were measured at different time points. Changes of serum procollagen type 1 N-terminal propeptide (P1NP) and collagen carboxyl-terminal degradation product type 1 (尾-CTX). Results at 6 months and 12 months after treatment, the bone mineral density (BMD) of the two groups increased in varying degrees. The BMD of lumbar vertebra, femoral neck, trochanter and total hip in the treatment group were significantly higher than those in the control group at the same period (P0.05). At 6 months and 12 months after treatment, the serum Ca,P, 尾-CTX and P1NP in the two groups were changed to some extent, the serum Ca,P, 尾-CTX was significantly lower than that before treatment, and the P1NP was significantly increased (P0.05). The changes in the treatment group were significantly higher than those in the control group (P0.05). Conclusion Atto vastatin combined with aspirin improves bone mineral density and bone biochemical and metabolic status in menopausal women with coronary heart disease.
【作者单位】：攀枝花市中心医院骨科;
【分类号】：R580

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