类风湿关节炎血清CCL19的表达及意义研究

发布时间：2019-04-15 13:38

【摘要】：目的检测类风湿关节炎(RA)患者血清中趋化因子CCL19的表达水平,并探讨其临床意义。方法收集2014年3月—10月中国医科大学附属盛京医院风湿免疫科住院的40例RA患者,18例骨关节炎(OA)患者和18名健康对照者。采用酶联免疫吸附试验(ELISA)法测定40例RA患者、18例OA患者和18名健康对照者血清中CCL19水平,比较组间差异,并分析血清CCL19与RA各临床及实验室指标的相关性。结果 RA组、OA组及对照组各组间血清CCL19水平差异有统计学意义(P0.01)。RA患者血清CCL19水平与疾病活动度评分(DAS28)、C反应蛋白(CRP)、红细胞沉降率(ESR)、类风湿因子(RF)、血小板(PLT)、免疫球蛋白Ig M呈正相关(P0.05),与血红蛋白(Hb)呈负相关(P0.05)。结论血清CCL19可能参与了RA的发病过程,有助于RA的鉴别诊断。
[Abstract]:Objective to detect the expression of chemokine CCL19 in serum of patients with rheumatoid arthritis (RA) and to explore its clinical significance. Methods from March to October, 2014, 40 RA patients, 18 (OA) patients with osteoarthritis and 18 healthy controls were enrolled in the Department of Rheumatology and Immunology, Shengjing Hospital, China Medical University. The serum CCL19 levels in 40 patients with RA, 18 patients with OA and 18 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). The differences between the two groups were compared. The correlation between serum CCL19 and clinical and laboratory indexes of RA was analyzed. Results there was a significant difference in serum CCL19 level among RA group, OA group and control group (P0.01) .Serum CCL19 level and disease activity score (DAS28), C reactive protein (CRP), erythrocyte sedimentation rate (ESR),) in patients with RA were significantly different (P0.01). Rheumatoid factor (RF), platelet (PLT), immunoglobulin Ig M was positively correlated (P0.05) and negatively correlated with hemoglobin (Hb) (P0.05). Conclusion Serum CCL19 may be involved in the pathogenesis of RA and may be helpful to differential diagnosis of RA.
【作者单位】：中国医科大学附属盛京医院风湿免疫科;
【基金】：辽宁省科学技术计划项目(2014225017)
【分类号】：R593.22

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