非布司他与别嘌呤醇治疗原发性痛风的疗效及其对胰岛素抵抗的影响研究

发布时间：2019-04-21 14:29

【摘要】：目的比较非布司他与别嘌呤醇治疗原发性痛风的疗效及其对胰岛素抵抗(IR)的影响。方法选取2013年11月—2015年5月首都医科大学附属北京朝阳医院门诊收治的符合纳入标准的原发性痛风患者52例为研究对象。使用SPSS 19.0软件将患者按1∶1的比例随机分为非布司他组(给予非布司他片)及别嘌呤醇组(给予别嘌呤醇片)。收集患者一般资料,分别检测患者治疗前和治疗24周末血清尿酸(UA)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、肌酐(Cr)、空腹血糖(FBG)、空腹胰岛素(INS)水平,计算稳态模型评估胰岛素抵抗指数(HOMA-IR)。结果治疗前两组UA、AST、ALT、Cr、FBG、INS水平和HOMA-IR比较,差异无统计学意义(P0.05);治疗后非布司他组UA、INS水平低于别嘌呤醇组(P0.05);治疗后两组AST、ALT、Cr、FBG水平和HOMA-IR比较,差异无统计学意义(P0.05)。别嘌呤醇组治疗后UA水平低于治疗前(P0.05);非布司他组治疗后UA、INS水平和HOMA-IR低于治疗前(P0.05)。结论非布司他比别嘌呤醇能更有效地控制原发性痛风患者血清UA水平,并能改善IR情况。
[Abstract]:Objective to compare the efficacy of non-bustane and allopurinol in the treatment of primary gout and its effect on insulin resistance (IR). Methods 52 patients with primary gout admitted to Beijing Chaoyang Hospital affiliated to Capital Medical University from November 2013 to May 2015 were selected as subjects. The patients were randomly divided into two groups: non-bustane group (given non-bustane tablets) and allopurinol group (given allopurinol tablets) according to the ratio of 1:1 with SPSS 19.0 software. General data of patients were collected and serum uric acid (UA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (ALT), creatinine fasting blood glucose (FBG), were detected before and 24 weeks after treatment. Fasting insulin (INS) level was measured and insulin resistance index (HOMA-IR) was evaluated by homeostasis model. Results there was no significant difference in the levels of UA,AST,ALT,Cr,FBG,INS and HOMA-IR between the two groups before treatment (P0.05), but the level of UA,INS in the non-bustane group was lower than that in the allopurinol group after treatment (P0.05). There was no significant difference in the level of AST,ALT,Cr,FBG and HOMA-IR between the two groups after treatment (P0.05). After treatment, the level of UA in allopurinol group was lower than that before treatment (P0.05), and the level of UA,INS and HOMA-IR in non-bustanol group after treatment was lower than that before treatment (P0.05). Conclusion non-bustane is more effective than allopurinol in controlling the level of serum UA in patients with primary gout and can improve the level of IR in patients with primary gout.
【作者单位】：首都医科大学附属北京朝阳医院风湿免疫科;
【分类号】：R589.7

【相似文献】