甲状腺不确定结节的回顾性细胞学评估研究（英文）

发布时间：2019-04-22 21:31

【摘要】：目的:回顾性分析了130例甲状腺不确定结节的临床评估和预后,以及组织细胞学检测结果,为甲状腺结节的治疗提供合理的治疗方法。方法:根据英国甲状腺协会2014年分类,回顾性分析了2011年1月至2014年12月130例甲状腺不确定结节(Thy 3)的细胞学检查。将结节分为Thy 3a(非典型特征)和Thy 3f(滤泡病变)两类。比较评估术前生物化学检查、彩色多普勒超声检查(US)、半定量弹性超声成像(USE)、超声造影(CEUS)、细胞学、组织学以及分子生物学突变分析等结果。结论:Thy 3结节的恶性肿瘤发生率较低,且在Thy 3a和Thy 3f之间没有显著差异。使用基于组织学的截取值作为参考可以降低采用手术的治疗方案。在阴性突变的Thy 3a和Thy 3f结节中,当不是所有的仪器检测结果都疑是阳性时,组织学观察应该作为首选。
[Abstract]:Objective: To retrospectively analyze the clinical evaluation and prognosis of 130 cases of thyroid indeterminate nodules, and to provide a reasonable treatment for the treatment of thyroid nodules. Methods: According to the 2014 classification of the British thyroid association, the cytological examination of the thyroid-indeterminate nodules (Thy 3) from January 2011 to December 2014 was analyzed retrospectively. The nodules were divided into Thy 3a (atypical) and Thy 3f (follicular lesions). The results of preoperative biochemical examination, color Doppler ultrasonic examination (US), semi-quantitative elastic ultrasound imaging (USE), ultrasonic contrast (CEUS), cytology, histology and mutation analysis of molecular biology were compared. Conclusion: The incidence of malignant tumor of Thy 3 nodules is low, and there is no significant difference between Thy 3a and Thy 3f. The use of histology-based intercept values can be used as a reference to reduce the treatment regimen using the procedure. In the negative mutated Thy 3a and Thy 3f nodules, the histological observation should be preferred when not all of the instrument test results were suspected to be positive.
【作者单位】： Endocrinology
【分类号】：R581

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