2型糖尿病和糖调节异常患者胰岛α、β细胞功能的变化
[Abstract]:Objective to investigate the changes of islet 伪 and 尾 cell function in patients with type 2 diabetes mellitus (T2DM) and abnormal glucose regulation (IGR). Methods from April 2014 to April 2016, 120 patients with T2DM and IGR were selected. Among them, 68 patients with T2DM (52 patients with), IGR in T2DM group (IGR group) and 40 healthy subjects as control group) were selected as control group to observe the secretion index of insulin homeostasis model (HOMA- 尾) in fasting state of each group. Insulin resistance index (HOMA-IR) level in insulin homeostasis model. Results the levels of blood glucose, glucagon and free fatty acid in T2DM group were (8.70 卤0.73) mmol/L, (210.11 卤40.14) nmol/L and (0.89 卤0.21) mmol/L, respectively, which were significantly different from those in IGR group (P 0.05). T2DM group was higher than IGR group. There was significant difference in insulin level between T2DM group and control group (P 0.05). There was significant difference in insulin level between); IGR group and control group (P 0.05). The HOMA-IR of T2DM group was 0.83 (0.42, 1.10), which was significantly different from that of IGR group and control group (P 0.05), while that of HOMA- 尾 was (3.61 卤0.72), which was significantly different from that of control group (P 0.05). Fasting glucagon was positively correlated with HOMA-IR level and negatively correlated with HOMA- 尾 in each group (P 0.05), while fasting glucagon was positively correlated with free fatty acid in T2DM group and IGR group (P 0.05). The insulin level of T2DM group was significantly different from that of IGR group and control group at oral glucose tolerance test 30, 60, 90 and 120 min (P 0.05). There was significant difference between), IGR group and control group (P 0.05). At 30, 60, 90 and 120 min of oral glucose tolerance test, the glucagon level in T2DM group was significantly higher than that in IGR group and control group (P 0.05). There was significant difference between), IGR group and control group (P 0.05). Conclusion the secretion of islet 伪 and 尾 cells in patients with T2DM and IGR is abnormal, and the levels of glucagon and free fatty acids are increased, which are correlated with the levels of HOMA-IR and HOMA- 尾.
【作者单位】: 湖北省武汉市第八医院内科;武汉大学人民医院内分泌科;
【基金】:国家自然科学基金(No:81170767)
【分类号】:R587.1
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