千金文武汤联合二甲双胍治疗太阴人2型糖尿病的临床研究
发布时间：2019-05-29 18:27
【摘要】：目的:通过朝医方"千金文武汤"联合二甲双胍(Metformin)对太阴人2型糖尿病(Type 2 Diabetes Mellitus,T2DM)(气阴两虚型)的治疗结果进行分析,观察临床疗效,评价朝医药治疗太阴人2型糖尿病的有效性和临床价值,为朝医方治疗糖尿病提供有效的科学依据。方法:将2015年3月至2016年12月期间,在延吉市中医医院和延边朝医医院门诊及住院部到访患者中,收集辨象为太阴人且患有2型糖尿病的患者60例,将其随机分为治疗组和对照组,各30例,两组均给予基础治疗(糖尿病知识教育;个体化的营养治疗;运动疗法)。对照组在基础治疗上口服盐酸二甲双胍片,0.5g/次,日2次;治疗组在对照组治疗基础上给予千金文武汤(葛根15g、山药15g、藁本15g、黄芩15g、五味子10g、麦门冬15g、桔梗10g、升麻10g、白芷10g)治疗。水煎400ml,200ml/次,日1剂。3周为1个疗程,连续观察3个疗程。药物治疗前先观察患者的中医症状,记症状积分,检查并记录餐后2小时血糖(2hPG)、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、甘油三酯(TG)、总胆固醇(TC),作为治疗前的有效数据。药物治疗结束后,观察治疗组与对照组各患者的症状变化,给相应的症状积分,分别记录治疗后的各项指标,最后统计治疗前后的FPG、2hPG、HbAlc、TG、TC(HDL-C;LDL-C)等生化指标的变化情况。得到数据以均数士标准差(x±S)表示,数据处理采用SPSS17.0中进行分析。结果:治疗组明显改善中医临床症状,优于对照组(P0.05)。两组均能降低血糖(FPG;2hPG),降低HbAlc,千金文武汤组比对照组的疗效更高(P0.05)。治疗组有效调节血脂异常,降低血脂指标,P0.05,对照组明显改善甘油三酯(TG),其余无统计学意义。调节TG方面,千金文武汤组优于对照组。结论:朝医方"千金文武汤"联合二甲双胍(Metformin)治疗太阴人2型糖尿病(T2DM)疗效明显,具有一定的治疗作用。可以改善T2DM患者的临床症状,降低血糖(FPG;2hPG),调节血脂、总胆固醇(HDL-C;LDL-C),比单纯用二甲双胍(Metformin)药物治疗更有优势。
[Abstract]:Objective: to analyze the therapeutic effect of "Qianjin Wenwu decoction" combined with metformin (Metformin) on type 2 diabetes mellitus (Type 2 Diabetes Mellitus,T2DM) in Taiyin people (deficiency of both qi and yin), and to observe the clinical effect. To evaluate the effectiveness and clinical value of Korean medicine in the treatment of type 2 diabetes mellitus in Taiyin people, and to provide an effective scientific basis for the treatment of diabetes mellitus with Korean medicine prescription. Methods: from March 2015 to December 2016, 60 patients identified as Taiyin and suffering from type 2 diabetes mellitus were collected from the outpatient and inpatient departments of Yanji City Hospital of traditional Chinese Medicine and Yanbian Chaoyi Hospital. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were given basic treatment (diabetes knowledge education). Individualized nutritional therapy; exercise therapy. The control group was treated with metformin hydrochloride tablets, 0.5g/ twice a day. On the basis of treatment in the control group, the treatment group was treated with Qianjin Wenwu decoction (Pueraria lobata 15g, yam 15g, ligusticum 15g, Scutellaria baicalensis Georgi 15g, Schisandra chinensis 10g, Ophiopogon miltiorrhiza 15g, Platycodon grandiflorum 10g, Gastrodia elata 10g, Angelica dahurica 10g). Water decoction 400 ml, 200 ml / time, 1 dose a day. 3 weeks as a course of treatment, continuous observation of 3 courses of treatment. Before drug treatment, the symptoms of the patients were observed, the symptom scores were recorded, and the postmeal blood glucose (2hPG) and fasting blood glucose (FPG), glycosylated hemoglobin (HbAlc), glycerol (TG), total cholesterol (TC), were examined and recorded. As a valid data before treatment. After drug treatment, the changes of symptoms in the treatment group and the control group were observed, the corresponding symptom scores were given, the indexes after treatment were recorded, and the FPG,2hPG,HbAlc,TG,TC (HDL-C;) before and after treatment was counted. The changes of biochemical indexes such as LDL-C). The obtained data are represented by mean standard deviation (x 卤S), and the data processing is analyzed by SPSS17.0. Results: the treatment group significantly improved the clinical symptoms of traditional Chinese medicine, better than the control group (P 0.05). Both groups could reduce blood glucose (FPG;2hPG), HbAlc, Qianjin Wenwu decoction group was more effective than the control group (P 0.05). The treatment group effectively regulated dyslipidemia and decreased the blood lipid index, P0.05, but the control group significantly improved the rest of TG (TG),. In regulating TG, Qianjin Wenwu decoction group was superior to the control group. Conclusion: Chaoyi recipe "Qianjin Wenwu decoction" combined with metformin (Metformin) is effective in the treatment of type 2 diabetes mellitus (T2DM) in patients with Taiyin. It can improve the clinical symptoms, reduce blood glucose (FPG;2hPG), regulate blood lipid and total cholesterol (HDL-C;LDL-C) in T2DM patients, which is more superior to metformin (Metformin) alone.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1
，
本文编号：2488128
[Abstract]:Objective: to analyze the therapeutic effect of "Qianjin Wenwu decoction" combined with metformin (Metformin) on type 2 diabetes mellitus (Type 2 Diabetes Mellitus,T2DM) in Taiyin people (deficiency of both qi and yin), and to observe the clinical effect. To evaluate the effectiveness and clinical value of Korean medicine in the treatment of type 2 diabetes mellitus in Taiyin people, and to provide an effective scientific basis for the treatment of diabetes mellitus with Korean medicine prescription. Methods: from March 2015 to December 2016, 60 patients identified as Taiyin and suffering from type 2 diabetes mellitus were collected from the outpatient and inpatient departments of Yanji City Hospital of traditional Chinese Medicine and Yanbian Chaoyi Hospital. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were given basic treatment (diabetes knowledge education). Individualized nutritional therapy; exercise therapy. The control group was treated with metformin hydrochloride tablets, 0.5g/ twice a day. On the basis of treatment in the control group, the treatment group was treated with Qianjin Wenwu decoction (Pueraria lobata 15g, yam 15g, ligusticum 15g, Scutellaria baicalensis Georgi 15g, Schisandra chinensis 10g, Ophiopogon miltiorrhiza 15g, Platycodon grandiflorum 10g, Gastrodia elata 10g, Angelica dahurica 10g). Water decoction 400 ml, 200 ml / time, 1 dose a day. 3 weeks as a course of treatment, continuous observation of 3 courses of treatment. Before drug treatment, the symptoms of the patients were observed, the symptom scores were recorded, and the postmeal blood glucose (2hPG) and fasting blood glucose (FPG), glycosylated hemoglobin (HbAlc), glycerol (TG), total cholesterol (TC), were examined and recorded. As a valid data before treatment. After drug treatment, the changes of symptoms in the treatment group and the control group were observed, the corresponding symptom scores were given, the indexes after treatment were recorded, and the FPG,2hPG,HbAlc,TG,TC (HDL-C;) before and after treatment was counted. The changes of biochemical indexes such as LDL-C). The obtained data are represented by mean standard deviation (x 卤S), and the data processing is analyzed by SPSS17.0. Results: the treatment group significantly improved the clinical symptoms of traditional Chinese medicine, better than the control group (P 0.05). Both groups could reduce blood glucose (FPG;2hPG), HbAlc, Qianjin Wenwu decoction group was more effective than the control group (P 0.05). The treatment group effectively regulated dyslipidemia and decreased the blood lipid index, P0.05, but the control group significantly improved the rest of TG (TG),. In regulating TG, Qianjin Wenwu decoction group was superior to the control group. Conclusion: Chaoyi recipe "Qianjin Wenwu decoction" combined with metformin (Metformin) is effective in the treatment of type 2 diabetes mellitus (T2DM) in patients with Taiyin. It can improve the clinical symptoms, reduce blood glucose (FPG;2hPG), regulate blood lipid and total cholesterol (HDL-C;LDL-C) in T2DM patients, which is more superior to metformin (Metformin) alone.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1
，
本文编号：2488128
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