2型糖尿病及糖尿病足患者血清唾液酸的变化及意义
发布时间：2019-06-28 09:32
【摘要】：目的研究2型糖尿病(T2DM)以及糖尿病足(DF)患者血清唾液酸(SA)的变化。方法检测93例T2DM患者和52例年龄、性别、体重指数(BMI)与之匹配的健康人群SA、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)。T2DM患者包括53例单纯糖尿病患者以及40例DF患者。同时对40例DF患者和52例健康人(正常对照组,NC组)血清SA绘制受试者工作曲线(ROC)并通过相关分析评价SA的价值。结果通过ROC确定血清SA的临界值为639.95 mg/L,对应的敏感度为87.5%,特异度为90.38%。DF患者SA明显高于T2DM组以及NC组(P0.05),且SA同FPG以及Hb A1c呈正相关。结论 SA在T2DM及DF中显著增加,检测血清SA对判断DF有重要意义。
[Abstract]:Objective to study the changes of serum sialic acid (SA) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot (DF). Methods fasting blood glucose (FPG), glycosylated hemoglobin (Hb A1c) was measured in 93 patients with T2DM and 52 healthy people with age, sex and body mass index (BMI). T2 DM patients included 53 patients with simple diabetes mellitus and 40 patients with DF. At the same time, the working curve (ROC) of 40 patients with DF and 52 healthy subjects (normal control group, NC group) was drawn and the value of SA was evaluated by correlation analysis. Results the critical value of serum SA determined by ROC was 639.95 mg/L, and the specificity of SA in 90.38%.DF group was significantly higher than that in T2DM group and NC group (P 0.05). There was a positive correlation between SA and FPG and Hb A1c. Conclusion SA is significantly increased in T2DM and DF. Detection of serum SA is of great significance in judging DF.
【作者单位】： 华中科技大学同济医学院附属梨园医院检验科;华中科技大学同济医学院附属梨园医院骨科;
【分类号】：R446.1;R587.2
本文编号：2507190
[Abstract]:Objective to study the changes of serum sialic acid (SA) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot (DF). Methods fasting blood glucose (FPG), glycosylated hemoglobin (Hb A1c) was measured in 93 patients with T2DM and 52 healthy people with age, sex and body mass index (BMI). T2 DM patients included 53 patients with simple diabetes mellitus and 40 patients with DF. At the same time, the working curve (ROC) of 40 patients with DF and 52 healthy subjects (normal control group, NC group) was drawn and the value of SA was evaluated by correlation analysis. Results the critical value of serum SA determined by ROC was 639.95 mg/L, and the specificity of SA in 90.38%.DF group was significantly higher than that in T2DM group and NC group (P 0.05). There was a positive correlation between SA and FPG and Hb A1c. Conclusion SA is significantly increased in T2DM and DF. Detection of serum SA is of great significance in judging DF.
【作者单位】： 华中科技大学同济医学院附属梨园医院检验科;华中科技大学同济医学院附属梨园医院骨科;
【分类号】：R446.1;R587.2
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