2型糖尿病患者血尿酸水平与胰岛功能相关性的研究

发布时间：2019-07-01 12:33

【摘要】：目的:本课题通过观察120例患者的血尿酸水平与胰岛功能各评估指标胰岛素分泌指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、早期胰岛素分泌功能指数(△I30/G30)、胰岛素曲线下面积(AUCI)、胰岛素曲线下面积/葡萄糖曲线下面积(AUCI/AUCG),期望发现血尿酸水平与胰岛β细胞分泌功能及抵抗程度的关系。以期为2型糖尿病(T2DM),尤其是合并高尿酸血症(HUA)的T2DM患者的早期治疗提供相关理论依据。方法:根据入排标准,收集2015年11月—2016年11月于我科住院的单纯T2DM患者60例,T2DM合并HUA患者60例作为观察对象。研究对象均知情同意。诊断均符合HUA诊断标准及1999年WHO 2型糖尿病诊断标准。记录病患的一般资料及生化检验指标。根据公式计算HOMA-β、HOMA-IR、△I30/G30、AUCI、AUCI/AUCG。统计学分析应用SPSS19.0完成。结果:1.单纯T2DM组与T2DM合并HUA组两组间胰岛分泌功能评估指标HOMA-β、△I30/G30、AUCI及胰岛素抵抗评估指标HOMA-IR、AUCI/AUCG差异均有统计学意义(P0.05);2.胰岛功能与UA水平相关性分析:患者HOMA-β、△I30/G30、AUCI,HOMA-IR、AUCI/AUCG与UA水平存在正相关性(r=0.610,r=0.277,r=0.197,r=0.496,r=0.220,p0.05)。3.两组间BMI、FPG、PBG、BUN、Scr、胱抑素、视黄醇有统计学差异(P0.05)。结论:1.与单纯T2DM患者相比,合并HUA患者IR程度更高;2.与单纯T2DM患者相比,合并HUA患者胰岛β细胞分泌功能升高。基础胰岛素分泌、第一时相胰岛素分泌、第二时相胰岛素分泌功能随着血尿酸水平的升高而增加;3.UA是影响胰岛β细胞分泌功能及IR的重要因素之一。
[Abstract]:Objective: to observe the serum uric acid level and insulin secretion index (HOMA- 尾), insulin resistance index (HOMA-IR), early insulin secretion index (I30/G30), area under insulin curve (AUCI), area under glucose curve (AUCI/AUCG). It is expected to find the relationship between serum uric acid level and islet 尾 cell secretion and resistance. In order to provide theoretical basis for early treatment of type 2 diabetes mellitus (T2DM), especially T2DM patients with hyperuricemia (HUA). Methods: according to the admission criteria, 60 patients with simple T2DM and 60 patients with T2DM complicated with HUA were collected from November 2015 to November 2016. All the subjects had informed consent. The diagnosis was in accordance with HUA diagnostic criteria and WHO type 2 diabetes mellitus diagnostic criteria in 1999. The general data and biochemical test indexes of the patients were recorded. According to the formula, HOMA- 尾, HOMA-IR, I30 鈮，

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