老年2型糖尿病患者血浆同型半胱氨酸的表达及其与骨密度的关系

发布时间：2019-07-27 09:08

【摘要】：目的探讨老年2型糖尿病(T2DM)患者血浆同型半胱氨酸(Hcy)的表达及与骨密度的关系。方法老年T2DM患者120例,根据骨密度水平将患者分为OP组(38例),骨密度降低患者为观察组(40例),骨密度正常患者为正常组(42例),另选择该院健康体检老年人40例为对照组;收集研究对象间基线资料,测定其血清钙(Ca)、血清磷(P)、血脂及骨密度,并分析各组间各项指标的差异。结果 OP组体质指数(BMI)及骨密度水平均低于其他3组,观察组BMI及骨密度低于正常组和对照组,OP组、观察组、正常组糖化血红蛋白(Hb A1c)均低于对照组(P0.05);OP组血清Hcy水平显著高于其他3组,观察组高于正常组和对照组,正常组亦高于对照组(P0.05);相关性分析发现,骨密度与BMI及Hb A1c均呈正相关(r=0.271、0.421;P0.05),与血清Hcy水平呈负相关(r=-0.554;P0.05)。结论机体血清Hcy水平升高可引起机体骨密度降低,是导致OP发生的危险因素,因此,老年T2DM患者应当控制机体血清Hcy水平。
[Abstract]:Objective to investigate the expression of plasma homocysteine (Hcy) and its relationship with bone mineral density (bone mineral density) in elderly patients with type 2 diabetes mellitus (T2DM). Methods 120 elderly patients with T2DM were divided into OP group (n = 38), observation group (n = 40) and normal group (n = 42) according to the level of bone mineral density (bone mineral density), and 40 elderly patients were selected as control group. The serum calcium (Ca), serum phosphorus (P), blood lipid and bone mineral density were measured and the differences among the groups were analyzed. Results the body mass index (BMI) and bone mineral density in OP group were lower than those in the other three groups. The BMI and bone mineral density in the observation group were lower than those in the normal group and control group, the glycosylated hemoglobin (Hb A1c) in the observation group and the normal group were lower than those in the control group (P 0.05). The serum Hcy levels in the); OP group were significantly higher than those in the other three groups, the observation group was higher than the normal group and the control group, and the normal group was also higher than the control group (P 0.05). Correlation analysis showed that bone mineral density was positively correlated with BMI and Hb A1c (r = 0.271, 0.421 卤0.05), and negatively correlated with serum Hcy level (r 鈮，

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