桥本甲状腺炎患者血清中白细胞介素-12、-17、-23和单核细胞趋化蛋白-1的表达

发布时间：2019-08-16 16:47

【摘要】：目的检测桥本甲状腺炎患者血清中白细胞介素(IL)-12、IL-17、-23和单核细胞趋化蛋白(MCP)-1的表达,探讨其临床意义。方法确诊为桥本甲状腺炎患者的血清标本59例为观察组,20例经体检证实为健康成人的血清标本为对照组,应用酶联免疫吸附试验(ELISA)检测两组血清中IL-12、IL-17、IL-23和MCP-1的表达。结果两组血清中IL-12、IL-17、IL-23和MCP-1的表达差异有统计学意义(P0.05)。观察组中IL-17、IL-23和MCP-1的表达与钙化灶密切相关,IL-12的表达与钙化灶无明显相关性,四者的表达与纤维化无关。线性相关分析显示观察组IL-17和IL-23呈正相关,其他指标间无相关性。结论桥本甲状腺炎患者血清中IL-12、IL-17、IL-23和MCP-1的表达升高,对病变的形成有重要作用。IL-17、IL-23和MCP-1升高可能与钙化灶的形成有一定关联性。
[Abstract]:Objective to detect the expression of IL-12, IL-17, IL-23 and monocyte chemotactic protein (MCP)-1 in serum of patients with Hashimoto's thyroiditis. Methods 59 serum samples from patients with Hashimoto's thyroiditis were selected as observation group and 20 healthy adults as control group. The expression of IL-12,IL-17,IL-23 and MCP-1 in serum of the two groups was detected by enzyme-linked immunosorbent assay (ELISA). Results there was significant difference in the expression of IL-12,IL-17,IL-23 and MCP-1 between the two groups (P 0.05). In the observation group, the expression of IL-17,IL-23 and MCP-1 was closely related to calcification, the expression of IL-12 was not significantly correlated with calcification, but the expression of IL-12 was not related to fibrosis. Linear correlation analysis showed that IL-17 and IL-23 were positively correlated in the observation group, but there was no correlation among the other indexes. Conclusion the increased expression of IL-12,IL-17,IL-23 and MCP-1 in serum of patients with Hashimoto's thyroiditis plays an important role in the formation of lesions. Il-17, IL / 23 and MCP-1 may be related to the formation of calcification.
【作者单位】：锦州医科大学附属第一医院内分泌科;
【分类号】：R581.4

【相似文献】