外周血白细胞介素-25和-33表达与慢性自发性荨麻疹患者病情的相关性研究

发布时间：2018-01-14 21:26

本文关键词：外周血白细胞介素-25和-33表达与慢性自发性荨麻疹患者病情的相关性研究　出处：《临床皮肤科杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的:探讨外周血中白细胞介素(IL)-25、IL-33的表达与慢性自发性荨麻疹患者病情严重程度的相关性。方法:慢性自发性荨麻疹患者75例,健康人对照30例,其中慢性自发性荨麻疹患者按病情分为轻、中、重3组。采用酶联免疫吸附试验检测外周血IL-25、IL-33水平,分析慢性自发性荨麻疹患者病情严重程度与IL-25、IL-33水平的相关性。结果:慢性自发性荨麻疹患者IL-25、IL-33水平分别为(149.58±25.47)ng/L、(95.41±25.59)ng/L,健康对照组分别为(120.52±28.16)ng/L、(80.25±25.03)ng/L,慢性自发性荨麻疹患者IL-25、IL-33水平较健康对照组显著升高(P0.01和0.05),且与患者病情呈正相关(r分别为O.54和0.67,均P0.01)。结论:IL-25、IL-33在慢性自发性荨麻疹患者外周血中表达水平升高,并与症状严重程度呈正相关。
[Abstract]:Objective: to investigate the relationship between the expression of IL-33 in peripheral blood and the severity of chronic spontaneous urticaria. Methods: 75 patients with chronic spontaneous urticaria were enrolled in this study. 30 healthy controls were divided into 3 groups according to their condition. The level of IL-25 IL-33 in peripheral blood was detected by enzyme linked immunosorbent assay (Elisa). To analyze the correlation between the severity of chronic spontaneous urticaria and the level of IL-25 IL-33. Results: IL-25 was found in patients with chronic spontaneous urticaria. The IL-33 levels were 149.58 卤25.47ng / L, 95.41 卤25.59ng / L, respectively. The healthy control group (n = 120.52 卤28.16 ng / L) was 80.25 卤25.03 ng / L, and IL-25 was found in patients with chronic spontaneous urticaria. The level of IL-33 was significantly higher than that of the control group (P0.01 and 0.05), and the positive correlation was 0.54 and 0.67, respectively. Conclusion the expression of IL-25 IL-33 in peripheral blood of patients with chronic spontaneous urticaria is higher than that of control group, and it is positively correlated with the severity of symptoms.
【作者单位】：连云港市第二人民医院皮肤科;
【分类号】：R758.24
【正文快照】： 荨麻疹是常见的变态反应性皮肤病,发病机制尚未完全清楚。研究表明慢性荨麻疹(CU)患者免疫功能异常,存在Thl/Th2失衡,约半数患者应属于自身免疫性荨麻疹[1-3]。白细胞介素(IL)-25、IL一33均是上皮细胞衍生细胞因子,均能诱发Th2型免疫应答,并促进IL-4、IL-5、IL-13等表达增加[4

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