miR-299-3P在早期梅毒及血清固定患者外周血单核细胞中的表达及临床意义

发布时间：2018-01-16 17:02

本文关键词：miR-299-3P在早期梅毒及血清固定患者外周血单核细胞中的表达及临床意义　出处：《中国皮肤性病学杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的探讨miR-299-3P在早期梅毒及血清固定患者外周血单核细胞(PBMC)中的表达及临床意义。方法收集2010年1月-2016年1月期间在该院皮肤性病中心诊断的早期梅毒、血清固定患者各35例,并收集35例健康志愿者作为对照组,QRT-PCR检测患者及健康志愿者PBMC中miR-299-3P水平;同时对血清固定患者miR-299-3P水平与RPR滴度及临床分期进行相关分析。结果梅毒血清固定患者外周血miR-299-3P水平明显高于早期梅毒及健康志愿者,差异有统计学意义(P0.05)。血清固定患者血清miR-299-3P水平与血清初始RPR固定滴度相关(P0.05),与临床分期无关(P0.05)。结论外周血单核细胞中miR-299-3P表达水平增高可能与梅毒血清固定相关。
[Abstract]:Objective to investigate the role of miR-299-3P in peripheral blood monocytes of patients with early syphilis and serum fixation. Methods from January 2010 to January 2016, early syphilis diagnosed in the skin venereal center of our hospital was collected. There were 35 patients with fixed serum and 35 healthy volunteers as control group. The miR-299-3P levels in PBMC were detected by RT-PCR in patients and healthy volunteers. At the same time, the correlation between miR-299-3P level and RPR titer and clinical stage in patients with serum fixation was analyzed. Results the level of miR-299-3P in peripheral blood of patients with syphilis fixed with serum was significantly higher than that in early stage. Syphilis and healthy volunteers. The difference was statistically significant (P 0.05). The level of serum miR-299-3P was correlated with the initial titer of RPR in patients with serum fixation (P 0.05). Conclusion the increased expression of miR-299-3P in peripheral blood monocytes may be related to serum fixation of syphilis.
【作者单位】：四川省成都市西区医院;第三军医大学西南医院皮肤科;四川大学华西第四医院皮肤科;
【分类号】：R759.1
【正文快照】： 梅毒血清固定是指部分患者经过正规驱梅方案治疗后,其快速血浆血清反应素(RPR)滴度下降至一定水平后不再变化并长期维持低滴度,即称为血清固定[1-2]。其发病机制一直不清楚,有学者认为与机体免疫功能密切相关,其中microRNA可能发挥着重要的调节作用。MicroRNA是一类长度约为21

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