天疱疮患者头发毛囊直接免疫荧光检测及其临床意义探讨

发布时间：2018-01-18 05:35

本文关键词：天疱疮患者头发毛囊直接免疫荧光检测及其临床意义探讨　出处：《中国皮肤性病学杂志》2015年11期 　论文类型：期刊论文

【摘要】：目的评价天疱疮患者头发毛囊直接免疫荧光检测的临床意义。方法每例患者头发约20根,采取直接染色方法进行直接免疫荧光检查。结果天疱疮患者毛囊直接免疫荧光示FITC标记的羊抗人IgG抗体在毛囊表皮下的外毛根鞘呈网状沉积,其荧光强度与天疱疮患者病情严重程度呈正相关(r=0.505,P0.05)。随访也发现,病情波动,毛囊DIF强度也随之变化,二者呈正相关。结论天疱疮患者毛囊直接免疫荧光强度在一定程度上反映与病情严重程度的相关性,推断对其强度的监测可用于评价疾病的严重程度并指导临床治疗。
[Abstract]:Objective to evaluate the clinical significance of direct immunofluorescence detection of hair follicles in pemphigus patients. Results the direct immunofluorescence of the hair follicles of the pemphigus patients showed that the sheep anti-human IgG antibody labeled with FITC deposited in the outer hair root sheath under the hair follicle epidermis. There was a positive correlation between the fluorescence intensity and the severity of pemphigus. It was also found that the DIF intensity of hair follicles changed with the fluctuation of the condition. Conclusion the direct immunofluorescence intensity of hair follicles in pemphigus patients is related to the severity of the disease to some extent. It is inferred that the intensity monitoring can be used to evaluate the severity of the disease and to guide clinical treatment.
【作者单位】：沈阳市第七人民医院皮肤科;中国医科大学附属第一医院皮肤科;
【分类号】：R758.66
【正文快照】： 天疱疮是一种自身免疫性表皮内水疱、大疱性皮肤黏膜疾病。在正常皮肤或黏膜上出现松弛性水疱,尼氏征阳性,血清中有天疱疮抗体[1]。病程中可见多次复发与缓解交替。糖皮质激素是目前该病的主要治疗药物,长期应用副作用大。直接免疫荧光(DIF)的检测,对了解治疗反应,指导临床的

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