他克莫司软膏治疗儿童特应性皮炎疗效和安全性的meta分析

发布时间：2018-02-02 08:04

本文关键词： 他克莫司特应性皮炎儿童 Meta分析有效性安全性　出处：《临床皮肤科杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的 :系统评价他克莫司软膏治疗儿童特应性皮炎的有效性及安全性。方法 :搜索电子数据库MEDLINE and PubMed、the Cochrane Central Register of Controlled(CENTRAL)、EMbase、中国知网、万方数据库以及维普数据库,检索时间从建库到2016年9月。检索他克莫司软膏治疗儿童特应性皮炎的随机对照试验(RCT)并根据Cochrane系统评价方法评价纳入文献质量,提取相关数据并用Stata/SE11.0软件进行meta分析。结果:最终纳入18个RCT共计2821例中到重度儿童特应性皮炎儿童患者。结果显示:(1)0.03%和0.1%他克莫司软膏可以有效治疗儿童特应性皮炎且无明显不良反应;(2)他克莫司软膏疗效优于氢化可的松软膏,但与甲泼尼龙和氟轻松相比差异无统计学意义;(3)0.1%与0.03%他克莫司软膏疗效及不良反应发生率差异无统计学意义。结论:外用他克莫司软膏可有效治疗儿童特应性皮炎,且具有较低的不良反应发生率。
[Abstract]:Objective: to evaluate the efficacy and safety of tacrolimus ointment in the treatment of atopic dermatitis in children. The Cochrane Central Register of controlled Internet. The Wanfang database and the Wiper database. Search time from the establishment of the library to September 2016. Search for tacrolimus ointment in the treatment of atopic dermatitis in children: a randomized controlled trial (RCTT). According to the evaluation method of Cochrane system, the literature quality was included. Extraction of relevant data and meta analysis with Stata/SE11.0 software. Results:. A total of 2 821 children with moderate to severe childhood atopic dermatitis were included in 18 RCT. (1) 0.03% and 0.1% tacrolimus ointment were effective in the treatment of atopic dermatitis in children. (2) tacrolimus ointment was better than hydrocortisone ointment, but there was no significant difference compared with methylprednisolone and fluorine easily. There was no significant difference in curative effect and adverse reaction rate between 0.1% and 0.03% tacrolimus ointment. Conclusion: topical tacrolimus ointment can effectively treat atopic dermatitis in children. And has a low incidence of adverse reactions.
【作者单位】：中国皮肤性病学杂志编辑部;西安交通大学第二附属医院皮肤科;陕西省中医医院皮肤科;
【分类号】：R758.2
【正文快照】： [J Clin Dermatol,2017,46(4):239-242]特应性皮炎(atopic dermatitis,AD)是一种慢性、炎症性皮肤疾病,多发病于儿童及婴幼儿[1]。临床以皮肤干燥、剧烈瘙痒,多形性皮损并伴有渗出、易复发等为主要特征,常并发哮喘、过敏性鼻炎等。AD具体发病原因尚不明确,已有的研究提示其可

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