隆突性皮肤纤维肉瘤手术切缘的体视学研究

发布时间：2018-02-04 01:23

本文关键词： skin neoplasms dermatofibrosarcoma protuburans stereology surgical therapy multiple linear regression mode　出处：《临床与实验病理学杂志》2010年02期 　论文类型：期刊论文

【摘要】：目的分析影响隆突性皮肤纤维肉瘤(DFSP)浸润性生长范围的主要因素,建立多元线性回归模型,探讨确定肿瘤手术切除范围的定量方法。方法将11例确诊DFSP病例按肿瘤生长部位分为躯干部和头颈部,运用体视学原理分别建立两组肿瘤浸润性生长范围(D)与瘤体半径(R)、年龄(age)和性别(sex)等变量的多元线性回归模型。结果不同部位关于肿瘤浸润性生长范围的回归模型均具有统计学意义(P0.05)。头颈部D1=0.1746+0.1404 R-1.9351sex+3.0754age1,方程的决定系数为0.65,调整决定系数为0.54,模型拟合效果较好,其肿瘤半径的回归系数为0.14(P=0.001),有统计学意义;躯干部回归方程中肿瘤半径的回归系数为-0.01(P=0.784),无统计学意义。结论通过对不同部位隆突性皮肤纤维肉瘤的分析研究,建立关于头颈部DFSP生长范围相对于该肿瘤大小,年龄及性别的数学模型,并对小于40岁男性发生于头颈部的DFSP的生长范围进行预测,当肿瘤最大径为1 cm、2 cm、3 cm时,肿瘤的切除范围分别不能小于0.8 cm、1.5 cm、3.1 cm。
[Abstract]:Objective to analyze the main factors affecting the invasive growth range of Dermatofibrosarcoma Carina (DFSP) and to establish a multivariate linear regression model. Methods Eleven patients with DFSP were divided into trunk and head and neck according to tumor growth site. The two groups of tumor invasive growth range (D) and tumor radius (R) were established by stereology. Results the regression models of tumor invasive growth range in different parts were statistically significant (P 0.05). Head and neck D1C0.1746 0.1404 R-1.9351sex 3.0754age1. The determination coefficient of the equation is 0.65, and the adjustment coefficient is 0.54. The regression coefficient of the tumor radius is 0.14 PX 0.001, which has statistical significance. The regression coefficient of tumor radius in the regression equation of trunk was -0.01 ~ 0.784g, which had no statistical significance. Conclusion the analysis and study of Carina dermatofibrosarcoma were carried out in different parts of the body. [WT5HZ] [WT5 "HZ] [WT5" HZ]. To establish a mathematical model of the growth range of head and neck DFSP in relation to the size, age and sex of the tumor, and to predict the growth range of DFSP occurring in the head and neck of men younger than 40 years old. When the maximum diameter of the tumor was 1 cm ~ 2 cm ~ (-2) cm ~ (-3) cm, the tumor resection range should not be less than 0.8 cm ~ (-1) cm ~ (-1) cm ~ (-1) ~ (-1) cm ~ (-1)
【作者单位】：安徽医科大学病理解剖学教研室;安徽医科大学第一附属医院整形外科;
【基金】：安徽省2008年度高等学校自然科学研究项目(KJ2009A057Z)
【分类号】：R739.5
【正文快照】： 隆突性皮肤纤维肉瘤(dermatofibrosarcoma pro-tuburans,DFSP)是发生于皮肤及皮下组织的交界性肿瘤,以局部浸润性生长、手术后容易复发为特征。病理组织学上特异性表现为细长的梭形细胞呈典型的席纹状或车辐状排列,肿瘤组织边缘可浸润脂肪组织呈蜂窝状结构或呈伪足状分支结构[

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