玉屏银屑方延长寻常型复发型银屑病缓解期的疗效观察及对T细胞亚群的影响

发布时间：2018-02-21 20:03

本文关键词： 寻常型银屑病复发型银屑病玉屏银屑方缓解期 T细胞亚群　出处：《山东中医药大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：观察玉屏银屑方延长寻常型复发型银屑病缓解期的疗效及预防干预用药前后患者外周血T细胞亚群水平的变化，初步探讨玉屏银屑方延长寻常型复发型银屑病缓解期的作用机理。方法：收集病例共87例，随机分为玉屏银屑方组30例（A组）、转移因子胶囊组27例（B组）和停药组30例（C组）。A组和B组治疗4周后停药，观察一年；C组入组即停药与A组做平行对照，观察一年。A组随机抽取20人，于入组前和治疗4周后进行外周血T细胞亚群检测，并与20个正常人T细胞亚群做对照分析。对所有入组患者随访观察一年，主要观察评估PASI、瘙痒程度、QOL、复发时间和不良事件。结果：T细胞亚群检测：A组患者治疗前，患者外周血T淋巴细胞亚群低于正常范围，治疗后T细胞亚群水平相比治疗前改善显著。临床观察结果分析：复发率比较，A组复发率明显低于C组。复发患者PASI评分比较，A组复发患者PASI评分显著低于C组，且A组复发患者PASI评分增加幅度明显低于C组。瘙痒程度比较，A组复发患者瘙痒程度显著低于C组，且A组复发患者瘙痒程度的增加幅度明显低于C组。入组患者QOL评分比较，A组患者结束观察研究时QOL评分非常显著低于C组，并进一步提示A组患者前后QOL评分减少数值非常显著大于C组。缓解时间比较，A组复发患者本次缓解期显著比C组延长，并进一步提示A组复发患者缓解期延长时间非常显著高于C组。 A组与B组以上临床观察结果分析各项比较均无显著差异，各项比较均基本持平。结论：玉屏银屑方能够显著延长寻常型复发型银屑病患者的缓解期，能够改善T细胞的免疫功能和免疫平衡。
[Abstract]:Objective: to observe the curative effect of Yuping Yinfeng recipe in prolonging the remission period of recurrent psoriasis vulgaris and the changes of T cell subsets in peripheral blood of patients with Psoriasis vulgaris before and after preventive intervention. Objective: to explore the mechanism of Yuping Yinfeng recipe in prolonging the remission period of recurrent psoriasis vulgaris. Methods: 87 cases were randomly divided into group A (30 cases), group A (27 cases), group B (27 cases), group B (30 cases), group C (30 cases) and group B (30 cases). The T lymphocyte subsets of peripheral blood were detected before and after 4 weeks of treatment in group A, and 20 patients in group A were randomly selected for one year. All the patients were followed up for one year to evaluate PASI, the degree of pruritus and QOLs, recurrence time and adverse events. Results before treatment, T lymphocyte subsets in peripheral blood of patients in group A were lower than those in normal range, and the level of T lymphocyte subsets was significantly improved after treatment. Analysis of clinical observation results: the recurrence rate in group A was significantly lower than that in group C, the PASI score in group A was significantly lower than that in group C, and the PASI score in group A was significantly lower than that in group C. The degree of pruritus in group A was significantly lower than that in group C, and the degree of pruritus in group A was significantly lower than that in group C. The degree of pruritus in group A was significantly lower than that in group C. the QOL score of group A was significantly lower than that of group C at the end of the study. It was further suggested that the decrease of QOL score in group A was significantly larger than that in group C. the remission time of group A was significantly longer than that of group C, and the remission time of group A was significantly longer than that of group C. It was further suggested that the duration of remission in group A was significantly longer than that in group C. There was no significant difference in clinical observation results between group A and group B. Conclusion: Yuping Yinfeng prescription can significantly prolong the remission period of patients with recurrent psoriasis vulgaris and improve the immune function and balance of T cells.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.63

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