IL-33与皮肤炎症性疾病关系的研究进展

发布时间：2018-02-26 14:34

  本文关键词： IL- 炎症 皮肤 综述　出处：《细胞与分子免疫学杂志》2014年09期 　论文类型：期刊论文

【摘要】：IL-33是IL-1细胞因子超家族的成员,组成性的表达于多种人类组织的细胞上,在皮肤组织细胞上呈现高表达。IL-33的特异性受体是转硫酶同系物(ST2),主要表达在Th2细胞、肥大细胞、巨噬细胞、树突状细胞、NK细胞和自然杀伤性T细胞等免疫细胞表面。IL-33的经典信号途径是通过ST2配体(ST2L)和IL-1受体辅助蛋白(IL-1RAP)组成的异二聚体,将信号转导至细胞内。IL-33是一种双效型的细胞因子,与皮肤多种炎症性疾病密切相关,尤其是银屑病和特应性皮炎,本文对IL-33及其在皮肤相关炎症性疾病的研究进展进行了综述。
[Abstract]:IL-33 is a member of the IL-1 cytokine superfamily, which is constitutively expressed in a variety of human tissue cells. The specific receptor for high expression of IL-33 in skin tissue cells is the S-transferase homologue ST2, which is mainly expressed in Th2 cells and mast cells. The classic signaling pathway of IL-33 on the surface of immune cells, such as macrophages, dendritic cells, NK cells and natural killer T cells, is the heterodimer composed of ST2 ligand ST2L) and IL-1 receptor helper protein IL-1RAP. The signal transduction to intracellular. IL-33 is a double acting cytokine, which is closely related to many inflammatory diseases of skin, especially psoriasis and atopic dermatitis. This article reviews the research progress of IL-33 and its role in skin related inflammatory diseases.
【作者单位】： 新乡医学院基础医学院免疫学教研室;新乡医学院第一附属医院皮肤科;
【基金】：河南省科技厅科技攻关项目(114300510012) 新乡医学院博士启动基金(BSQD2013008)
【分类号】：R751
，

本文编号：1538421