若干分子标志物及临床特征与恶性黑色素瘤预后的多因素相关分析

发布时间：2018-02-27 05:17

本文关键词： 恶性黑色素瘤预后生存分析 HMB S- Vimentin　出处：《南方医科大学学报》2012年06期 　论文类型：期刊论文

【摘要】：目的评估若干分子标志物及临床特征对恶性黑色素瘤(MM)预后的影响。方法回顾性分析127例MM患者的临床资料;对127例MM标本以免疫组化法检测HMB45、S-100以及Vimentin蛋白的表达;COX比例风险回归模型对各临床病理指标进行单因素和多因素生存分析。结果 HMB45、S-100以及Vimentin在MM中的阳性表达率分别为89.8%、92.1%和78.0%;单因素分析提示影响MM预后的因素包括年龄、原发病灶是否溃疡、Clark分级、术后病灶切缘情况、AJCC分期、治疗方法及疗效、S-100蛋白(P0.05);多因素分析发现年龄、术后切缘情况、Clark分级、S-100蛋白以及疗效是影响MM预后的独立因素。结论年龄、术后切缘情况、Clark分级、S-100蛋白与疗效是影响MM预后的独立危险因素,HMB45和Vimentin蛋白表达水平与MM预后不相关。
[Abstract]:Objective to evaluate the effect of molecular markers and clinical features on the prognosis of malignant melanoma (MMM). Methods the clinical data of 127 cases with MM were analyzed retrospectively. Using immunohistochemical method to detect HMB45 S-100 and the expression of Vimentin protein and Cox proportional risk regression model, the survival analysis of each clinicopathological index was carried out. Results the positive expression rate of HMB45 S-100 and Vimentin in MM was analyzed by single factor and multivariate analysis. The univariate analysis showed that the factors influencing the prognosis of MM included age. Whether the primary lesion was ulcerated or not was Clark's grade, the incised margin of the lesion after operation and the stage of AJCC, the treatment method and the effect of S-100 protein P0.05.The age was found by multivariate analysis. Clark grade S-100 protein and curative effect were independent factors influencing the prognosis of MM. The expression of HMB45 and Vimentin protein was not correlated with the prognosis of MM.
【作者单位】：南方医科大学南方医院肿瘤中心;
【基金】：广东省自然科学基金重点项目(10251051501000008)
【分类号】：R739.5

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