皮肤Merkel细胞癌2例临床病理分析

发布时间：2018-03-02 21:44

本文选题：皮肤肿瘤　切入点：Merkel细胞癌　出处：《临床与实验病理学杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨皮肤Merkel细胞癌(Merkel cell carcinoma,MCC)的临床病理特征、免疫表型、诊断和鉴别诊断。方法回顾性分析2例MCC的临床及病理学特点,并复习相关文献。结果 2例患者均为老年男性,全身肿瘤多发,镜下见2例肿瘤主要位于真皮及皮下组织,未侵及表皮,肿瘤组织均由大小较一致的肿瘤细胞弥漫呈片、巢状分布,瘤细胞体积较小,胞质稀少,核圆形或椭圆形,深染,核膜清楚,核仁不明显,核分裂象易见,并可见神经浸润现象。免疫组化标记示上皮和神经内分泌分化阳性,例1 CK20呈特征性的核旁点状阳性,例2 CK7阳性/CK20阴性在MCC中较为少见。结论MCC恶性程度高,临床较为罕见,应与其他小细胞肿瘤鉴别。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of cell carcinoma of Merkel cell carcinoma of skin. Methods the clinical and pathological features of 2 cases of MCC were retrospectively analyzed and the relevant literature was reviewed. The tumors were mostly located in dermis and subcutaneous tissue, but not in epidermis. The tumor tissues were all distributed in the same size, the tumor cells were small in size, and the cytoplasm was rare, and the tumor tissues were mainly located in the dermis and subcutaneous tissues, but not in the epidermis. The nucleus was round or ellipse, deep stained, clear nuclear membrane, not obvious nucleolus, mitotic image, and the phenomenon of nerve infiltration. Immunohistochemical staining showed that the epithelial and neuroendocrine differentiation was positive. In case 1, CK20 showed characteristic parafronucleus dot positive. Case 2 CK7 positive / CK20 negative was rare in MCC. Conclusion MCC is highly malignant and rare in clinical practice, and should be distinguished from other small cell tumors.
【作者单位】：山东大学附属省立医院病理科;解放军总医院第一附属医院病理科;
【分类号】：R739.5

【相似文献】