影响斑秃病情的相关因素分析

发布时间：2018-03-03 19:12

本文选题：斑秃　切入点：相关因素　出处：《广州医学院》2011年硕士论文　论文类型：学位论文

【摘要】：目的:研究斑秃患者的临床特征,分析影响斑秃病情轻重的相关因素,为临床诊治和预后判定提供依据。方法:收集我院皮肤科门诊就诊的314例斑秃患者的临床资料,对性别、年龄、初发病年龄、病程、复发、脱发面积、伴随个人和/或及家族中过敏性疾病史、自身免疫性疾病史、家族史和甲病变等临床特征进行统计分析。计量资料采用t检验,计数资料比较采用χ2检验,并进行多因素Logistic回归分析。结果:314例斑秃患者中,男性160例(50.9%),女性154例(49.1%),男女性别比为1.04:1。初发病年龄为1～74岁,平均初发病年龄为(28.48±14.05)岁。病程为1天～18年,中位病程为4月。轻型AA (轻型组) 198例(63.1%),重型AA (重型组) 116例(36.9%)。10.1%的斑秃患者家族史阳性,36.9%的斑秃患者伴随甲病变,15.6%的斑秃患者有个人和/或家族性过敏性疾病史,5.4%斑秃患者有自身免疫性疾病史。重型组的病程显著长于轻型组(t=-7.337, P 0. 05),初发病年龄显著小于轻型组(t=2.910, P 0. 05),伴随有甲病变所占的比例显著高于轻型组(χ2 =28.784, P 0. 05),轻型组与重型组之间性别、复发、伴随个人和/或家族性过敏性疾病史、自身免疫性疾病史和家族史所占比例比较,差异均无统计学意义(P均0.05)。经多因素Logistic回归分析,病程、初发病年龄和伴随甲病变与斑秃病情严重程度有关。结论:病程、初发病年龄和伴随甲病变与斑秃病情严重程度有关。病程长、初发病年龄早和伴随甲病变是重型斑秃的危险因素。斑秃病情的严重程度与性别、复发、家族史、伴有个人和/或家族中过敏性疾病史和自身免疫性疾病史无关。
[Abstract]:Objective: to study the clinical features of patients with alopecia areata and analyze the related factors affecting the severity of alopecia areata. Methods: the clinical data of 314 patients with alopecia areata were collected, including sex, age, age of onset, course of disease, recurrence, area of alopecia alopecia, history of allergic diseases in individuals and / or families. The clinical features of autoimmune disease history, family history and nail lesion were statistically analyzed. T test was used to measure the data, 蠂 2 test was used to compare the count data, and multivariate Logistic regression analysis was carried out. Results among 314 cases of alopecia areata, 160 cases were male and 154 cases were female. The sex ratio of male to female was 1.04: 1.The age of onset was 1 ~ 74 years, the average age of onset was 28.48 卤14.05), the course of disease was from 1 day to 18 years. The median course of disease was April. There were 198 patients with mild AA (light group) and 116 patients with severe AA (severe group). 36.9% of the patients had positive family history of alopecia areata and 15.6% of patients with alopecia areata had personal and / or familial allergic diseases. The course of disease in the severe group was significantly longer than that in the light group (P 0.05), and the initial onset age was significantly lower than that in the light group (2.910, P 0.05), and the proportion of patients with thyroid disease was significantly higher than that in the light group (蠂 2 28.784, P < 0.05), and the incidence of Areopecia areata in the severe group was significantly longer than that in the mild group (蠂 2 28.784, P < 0.05). P 0.05, sex between light group and severe group, There was no significant difference in the proportion of recurrent patients with individual and / or familial allergic disease history, autoimmune disease history and family history (P < 0.05). The course of disease was analyzed by multivariate Logistic regression analysis. The age of onset and associated nail lesions were associated with the severity of alopecia areata. Conclusion: the severity of alopecia areata is related to the course of disease, the age of initial onset and the concomitant nail lesion. The long course of disease, the early age of onset and accompanying nail lesion are the risk factors of severe alopecia areata, the severity and sex of alopecia areata disease, recurrence, family history, etc. There is no correlation between the history of allergic diseases and autoimmune diseases in individuals and / or families.
【学位授予单位】：广州医学院
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.71

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